酰基吡唑啉酮缩氨基酸席夫碱的合成及与稀土配位性能和生物活性研究  

Synthesis of Acylpyrazolone-Amino-Acid Schiff Base Rare Earth Complexes and Its Bioactivity

作　　者：李锦州[1] 蒋礼[1] 安郁美[1] 

机构地区：[1]哈尔滨师范大学化学系,黑龙江哈尔滨150080

出　　处：《中国稀土学报》2004年第2期189-192,共4页Journal of the Chinese Society of Rare Earths

基　　金：教育部重点科研基金(02053);黑龙江省自然科学基金(B01 06);省高校骨干教师创新计划资助项目

摘　　要：合成了氨基酸席夫碱试剂1 苯基 3 甲基 4 (α 呋喃甲酰基)吡唑啉酮 5缩β 丙氨酸(HL)及其10个稀土配合物。元素分析及摩尔电导值表明新配合物的组成为[REL2NO3]·nH2O(RE=La,Pr,Eu,Y,n=2;RE=Nd,Sm,n=1;RE=Tb,Dy,Er,Yb,n=3)。运用红外光谱、紫外光谱、核磁共振谱和荧光光谱对配合物进行了表征。抗菌实验表明配合物具有较强的抗菌生物活性。A new amino-acid Schiff base, 1-phenyl-3-methyl-4-(α-furoyl) pyrazolone-5-β-alanine (HL) and its ten rare earth complexes were synthesized. On the basis of elemental analysis and molar conductance, the general formula of the complexes, [REL_2NO_3 ]·nH_2O (RE=La, Pr, Eu, Y, n=2; RE=Nd, Sm, n=1; RE=Tb, Dy, Er, Yb, n=3), is given. They were characterized by IR, UV-visible, (()~1H) NMR, (()^(13)C) NMR and fluorescence. The results show that the rare earth ions exhibit coordination of eight in the complexes.The antibacterial experiments indicate that they have high antibacterial activities against S. aureus, B. subtillis, E.coli, E.carotovora and C. flaccumfaciens.

关 键 词：无机化学 呋喃甲酰基吡唑啉酮缩β-丙氨酸 席夫碱 生物活性 稀土 

分 类 号：O614.33[理学—无机化学] O626.21[理学—化学]