益气活血胶囊抗心肌梗塞后早期左室重构的临床观察  

Clinical Observation on Effect of Yiqi Huoxue Capsule in Treating Early Ventricular Remodeling After Myocardial Infarction

作　　者：黄小平[1] 洪蓉蓉[1] 

机构地区：[1]广州中医药大学第一附属医院,广州510405

出　　处：《广州中医药大学学报》2004年第3期185-187,共3页Journal of Guangzhou University of Traditional Chinese Medicine

摘　　要：【目的】观察益气活血胶囊抗心肌梗塞后早期左室重构的效应。【方法】将 90例急性心肌梗塞 (AMI)病人随机分为益气活血胶囊组和安慰剂组 ,每组各 4 5例 ,在给予溶栓治疗和 /或常规治疗基础上分别给予益气活血胶囊或安慰剂治疗。治疗后 1周、 8周分别检测两组间的室间隔厚度 (IVS)、左室后壁厚度 (LVPW)、左室舒张末内径 (LVDd)、局部室壁运动记分和左室射血分数 (LVEF)。【结果】安慰剂组AMI后 8周的IVS、LVPW及LVDd较AMI后 1周时明显增加 ,而益气活血胶囊组则未见明显增加 ,两组间比较差异具有显著性意义 (P <0 0 5 ) ;安慰剂组局部室壁运动记分增加 ,而益气活血胶囊组无明显改变 ,两组间比较具有显著性差异 (P <0 0 5 ) ;安慰剂组LVEF下降 ,益气活血胶囊组则增加 ,差异具有显著性意义 (P <0 0 5 )。【结论】中药复方制剂益气活血胶囊可抑制AMI后舒张末内径的扩大 ,减轻室间隔及非梗塞区的代偿性肥厚 ,改善心室局部运动障碍和整体左室功能 ,具有一定的抗心室重构作用。To investigate the effect of Yiqi Huoxue Capsule (YHC) in treating early ventricular remodeling after myocardial infarction.Ninety cases of acute myocardial infarction (AMI) were randomized to two groups: YHC group (A) and placebo group (B). Groups A and B were treated with YHC and placebo respectively on the basis of thrombolytic treatment and/or routine western treatment. Interventricular septum (IVS) thickness, left ventricular posterior wall (LVPW) thickness, left ventricular dimension in end-diastole (LVDd), scoring of local ventricular wall function and left ventricular ejection fraction (LVEF) were observed 1 and 8 weeks after treatment. Eight weeks after treatment, IVS thickness, LVPW thickness and LVDd were increased and scoring of local ventricular wall function was also increased in group B as compared with those one week after treatment;no obvious changes were found in group A and the difference was significant between the two groups (P<0.05); LVEF was decreased in group B and increased in group A, the difference being significant between the two groups (P<0.05).[Conclusion]YHC has certain effect in counteracting ventricular remodeling by inhibiting the enlargement of LVDd after AMI, reducing compensatory hypertrophy of interventricular septum and non-infarction region,and improving the local ventricular dyskinesia and over-all ventricular function.

关 键 词：益气活血胶囊 心肌梗塞 左室重构 心室复建 AMI 

分 类 号：R259.422.2[医药卫生—中西医结合]