消炎痛对巨噬细胞分泌白细胞介素1的影响  

EFFECTS OF INDOMETHACIN ON INTERLEUKIN 1 SECRETED BY MACROPHAGES

作　　者：裴仁九[1] 赵明敏[2] 於传斌[2] 

机构地区：[1]南京军区福州总医院临床药理基地,350001 [2]蚌埠医学院药理学教研室

出　　处：《蚌埠医学院学报》1993年第1期16-17,共2页Journal of Bengbu Medical College

摘　　要：本文探讨消炎痛(IM)对LPS诱导M_φ产生IL-1及LPS与M_φ作用时间对于IL-1产生和分泌的影响,表明IM(10μmol/L)可显著增加IL-1的产生和分泌;LPS与M_φ作用6h即可充分激发IL-1分泌。因此,LPS加IM和药物与M_φ培养数小时后更换新鲜培养液是在研究药物对IL-1分泌活性影响时的一种简便、实用、可靠的方法。The effects of indomethacin (IM) and the incubation time of LPS with macrophages on LPS - stimulated macrophage IL-1 production were studied. It was showed that IM(10μmol/L) could signi fcantly enhance, the production and secretion of IL-1. LPS cultured with macrophages for 6 hours could stimulate IL-1 secretion So changing a fresh medium several hours after incubation of macrophages with LPS, IM and certain drug is simple, practical and reliable for researching effects of certain drug on IL-1 secretion activity.

关 键 词：白细胞介素1 巨噬细胞 吲哚氯甲酰 

分 类 号：R969[医药卫生—药理学]