SOD对小白鼠实验性胃溃疡的治疗保护作用  

THE TREATMENT AND PROTECTIVE EFFECT OF SUPEROXIDE DISMUTASE ON THE EXPERIMENTAL GASTRIC ULCERS IN MICE

作　　者：赵明敏[1] 葛敏[1] 李远文[2] 王洛夫[3] 

机构地区：[1]蚌埠医学院药理学教研室 [2]安徽中医学院 [3]蚌埠医学院核医学教研室

出　　处：《蚌埠医学院学报》1993年第3期147-149,共3页Journal of Bengbu Medical College

摘　　要：SOD对小鼠IM-HCl胃溃疡呈明显保护效应,其对点、条状溃疡形成的抑制作用显著,治疗组平均点、条状溃疡数和点状溃疡发生率均比未治疗组有明显降低(P<0.05),但条状溃疡发生率差异无显著性.病理和生化学检查佐证,治疗组粘膜病变程度明显减轻,粘膜MDA含量未见增加.未治溃疡组MDA含量却有极显著性增高(P<0.001).表明胃粘膜微循环中氧自由基参与粘膜病变的发生和发展起重要作用,预测外源性SOD对胃粘膜损伤或溃疡病变的防治,具有临床意义.We found that markedly protective effect of Superoxide dismutase(SOD)on the gastric ulcers induced by IM and HC1,inhibited the gastric lesion (spot and linear shape) was significantly. The average numbers of gastric lesions (spot and linear shape) and the spot shape of the gastric lesions produced percentage in the treatment group were lower than the untreatment group (P<0. 05). But no significant difference in the gastric lesions (linear shape) produced percentage was observed. The data of the pathological and biochemistrical examination showed that the pathological changes of the mucosal membranes to be remission markedly and no increase in the mucosal membranes MDA in the treatment group. But this results suggested that the oxygen free radicals in gastric mucosal membranes participation in the production and development of the mucosal membranes lesions played an important role. We consider that there is a clinical value of superoxide dismutase in the prevention and treatment of the mucosal membranes lesions or ulcers.

关 键 词：胃溃疡 超氧物歧化酶 小鼠 药理 

分 类 号：R969.4[医药卫生—药理学]