探讨快速输注不同血浆代用品对凝血功能的影响  

Probe the Different Impacts on Blood Coagulation Function by Fast Transfusing the Plasma Substitute

作　　者：刘燕君 肖晓山 高燕平 

机构地区：[1]广东省一七七医院,广州510317

出　　处：《现代护理》2004年第5期395-397,共3页Modern Nursing

摘　　要：目的　探讨目前临床常用的几种人工血浆代用品在术前进行快速输注 (实验性输液 )后对凝血功能的影响。方法　选择择期行腰椎间盘摘除术的男性手术患者 4 0例。全部病例均无贫血、出凝血功能障碍以及肝、肾等重要脏器疾病 ,无近期用非甾体抗炎药史。按不同液体将患者随机分为平衡液 (L)、6 %羟乙基淀粉 (H)、血定安 (G)和聚明胶肽 (F)四组。按设计要求以 0 .3ml/ (kg·min)的输注速率输注完 5 0 0ml液体。详细记录实验前 (T0 )、实验性输液 10min后 (T1)及实验性输液结束即刻 (T2 )的MAP、HR和SpO2 。分别于实验性输液前、实验性输液后测定血小板计数PLT、凝血酶原时间PT、部分活化凝血酶原时间APTT。结果　实验性输液期间 ,四组患者HR、MAP和SpO2 保持稳定 ,均在正常范围内 ,T1、T2 与T0 比较无统计学差异。实验性输液后PLT、FBG均有不同程度下降和减少 ,除贺斯组外 ,其它三组与实验性输液前比较有显著性差异 ,P <0 .0 5 ,其中以平衡液组最为明显 ,其次是聚明胶肽组 ,血定安组和 6 %羟乙基淀粉组差不多 ;实验性输液后PT、ACT、APTT四组均有明显的延长 ,P <0 .0 5 ,似乎平衡液组更明显。结论　快速输注适量平衡液、羟乙基淀粉、血定安和聚明胶肽溶液 ,可影响凝血指标的测定值 ,但对凝血功能无明显影响 ,?Objective Probed into the impact on blood coagulation function after the clinical artificial plasma substitutes were fast transfused (experimental infusion) in pre-operation. Methods 40 male patients of waist intervertebral disc excise operation which was selected a time to do. All cases did not have important internal organs diseases, such as anaemia, getting off the function obstacle of blood coagulation and diseases of liver, kidney, etc., did not have the history that the steroid body resisted the inflammation medicine recently. According to different liquid, the patients were divided into the balance liquid (L), 6% hydroxyl second base starch (H), Xuedingan (G) and gather gelatin peptide (F) 4 groups at random. According to designing requirement, 500ml liquid was transfused at the speed of 0.3ml/ (kg·min). And the experimental infusion finished MAP, HR and SpO2 at once (T 2) before the detailed record experiment (T 0), after experimental infusion 10min (T 1). Before experimental infusion and after experimental infusion, blood platelet count PLT, blood coagulation zymogen time PT, activate zymogen time coagulation APTT of blood were separately determined. Results During the experimental infusion, four groups of patients HR, MAP and SpO 2 remained stable, and in the normal range, there is not statistics difference between T 1, T 2 and T0 relatively. PLT, FBG drop and reduce in various degrees after the experimental infusion. Except congratulating group, there are relatively significance differences between the other three groups and experimental infusion, P<0.05. Among them the balanced liquid group is the most obvious. The second is the gathering gelatin peptide group, and the group of Xuedingan is similar to second base starch group of 6% of the hydroxyl. There is obvious extension in PT, ACT, APTT four groups after the experimental infusion, P<0.05, it seems that the liquid group of the balance is more obvious. Conclusions Transfusing and balance liquid, second base starch of hydroxyl, Xuedingan

关 键 词：人工血浆代用品 快速输注 凝血功能 

分 类 号：R472.2[医药卫生—急诊医学]