重组人G-CSF对放化疗引起乳腺癌患者白细胞减少症的疗效观察  

A Brief Report on Effect of rhG-CSF in Treating Leukopenia After Radio-and Chemo-therapy of Patients with Breast Cancer

作　　者：王铁君[1] 刘林林[1] 程光惠[1] 刘晓兰[1] 曲雅勤[1] 吴镇凤[1] 张崇芳[1] 

机构地区：[1]吉林大学第二医院放疗科

出　　处：《中国实验血液学杂志》2004年第3期381-382,共2页Journal of Experimental Hematology

摘　　要：为了观察国产粒细胞集落刺激因子rhG CSF(粒生素 )在放化疗中对白细胞减少症的治疗作用 ,对 10 0例经病理证实的乳腺癌根治术后患者 ,随机分为观察组和对照组各 5 0例 ,两组病人均于术后 2周始行 1个周期CAF方案化疗 ,然后放疗。观察组在化疗中加用粒生素 75微克 天 ,皮下注射 ,连用 5 - 7天 ,在放疗过程中针对不同程度的白细胞减少再应用 3- 5天。对照组在放化疗中不用粒生素。比较两组病人白细胞和中性粒细胞绝对数的动态变化。结果表明 ,观察组患者白细胞及中性粒细胞的最低值均明显高于对照组 ,未见明显副作用。结论 :粒生素对放化疗过程中白细胞减少的治疗效果确切 ,副作用不明显。The study was to observe the effect of rhG-CSF (lishengsu) in treating leukopenia caused by radiotherapy and chemotherapy in patients with breast cancer. 100 cases of breast cancer received modified radical mastectomy were randomized into two groups with the same treatment of one cycle chemotherapy using the protocal of CAF at two weeks after the operations and then radiotherapy. The patients in treated group received rhG-CSF 75 μg per day s.c. for 5-7 days constantly,and additional 3-5 days according to leukopenia during radiotherapy. The patients in control group did not receive rhG-CSF during the chemo-and radio-therapy. The results shows that nadir of WBC and neutrophil counts in the treated group was higher than that in control significantly. In conclusion,effect of lishengsu on leucopenia in process of chemotherapy and radiotherapy shows definite therapeutic effect,the side effects are not remarkable.

关 键 词：重组人粒细胞集落刺激因子 白细胞减少症 乳腺癌 

分 类 号：R973.4[医药卫生—药品] R57.1[医药卫生—药学]