无生命材料参与有生命组织的过程  

Process of non-life materials participating in life tissue

作　　者：李世普[1] 戴红莲[1] 闫玉华[1] 沈春华[1] 江昕[1] 

机构地区：[1]武汉理工大学生物材料与工程研究中心,武汉430070

出　　处：《中国有色金属学报》2004年第F01期337-340,共4页The Chinese Journal of Nonferrous Metals

基　　金：国家重点基础研究发展规则项目(G1999064701)

摘　　要：探讨细胞对可降解多孔磷酸三钙陶瓷(β TCP)降解的影响及材料骨内植入后在体内超微结构的变化,研究了磷酸三钙陶瓷的生物降解、新骨生成过程及结构的变化,为可降解钙磷材料的生物降解和骨生成机制提供依据。研究结果表明,材料在体内超微结构的变化是影响材料降解的重要因素之一;钙磷材料通过溶解沉积参与新骨形成,以OCP,DOHA和HAP的形式存在于骨胶原纤维中,与其他有机质一起构成新骨。The effect of cells on the biodegradation of porous tricalcium phosphate (β-TCP) and the ultrastructure transformation of the materials after implantation were studied. The process of biodegradation, new-bone formation and structural change of calcium phosphate ceramics were also investigated. The results provide the direct evidence of the mechanism of biodegradation and osteogenesis for biodegradable calcium-phosphor (Ca-P) ceramics, and show that the ultrastructural transformation of Ca-P in vivo is one of the important factors of biodegradation. No-life Ca-P materials participate in new-bon formation by force of dissolution and deposition. It constitutes bone tissue with other organics together in the form of OCP, DOHA and HAP, which consist in osteocollagenous fibers.

关 键 词：磷酸三钙陶瓷 生物降解 超微结构 Β-TCP 生物材料 

分 类 号：R318.08[医药卫生—生物医学工程]