参麦注射液对糖尿病合并急性心肌梗死患者血液流变学的影响  

Effects of Shengmai injection on Hemorrheology in Diabetic Patients with AMI

作　　者：李永洪[1] 官明德[1] 李莉[1] 吴少萍 石玫[1] 朱为勇[1] 

机构地区：[1]青岛医学院第二附属医院心内科,山东青岛266041 [2]青岛万杰医院心电图室,山东青岛266061

出　　处：《医学新知》2004年第2期86-88,共3页New Medicine

摘　　要：目的　探讨参麦注射液对糖尿病合并急性心肌梗死 (AMI)患者血流变学改变的疗效及作用机制。方法　 6 0例糖尿病合并急性心肌梗死患者随机分为参麦组和鲁南欣康 (鲁南 )组 ,每组 30例。除常规心梗治疗外 ,参麦组静脉注射参麦液 4 0ml/d ,鲁南组静脉注射 5 单硝酸异山梨酯 2 0mg/d ,疗程 4周 ,于治疗前后及用药过程中监测心肌酶、心电图与血液流变学等指标。结果　参麦组总有效率 86 .6 7% ,显著高于鲁南组 (70 .0 0 % ) ;在降低心肌酶、改善心电图及血流变学方面的作用均较鲁南欣康注射液显著 (P <0 .0 1) ,且副作用显著低于后组。结论　参麦注射液具有保护心肌 ,改善微循环 ,降低血液粘滞度等作用 ,对糖尿病患者合并急性心肌梗死异常血流变的疗效确切 ,副作用少 ,较鲁南欣康效果显著。Objectives To evaluation the therapeutic effects and mechanism of Shengmai injection on patients with acute myocardial infarction (AMI) and diabetes.Methods Sixty AMI-patients with diabetes were randomly assigned to two groups. One group was treated with 30 ml Shengmai injection and another group treated with 20 mg Isordil injection once a day, in addition to basic therapy, for 4 weeks. Hemorrheology, total Q waves (∑Q)、heart rate (HR), systolic blood pressure (SBP),Killip class、creatine phosphokinase(CPK) and CPK-MB were measured before and after therapy in both groups.Results The total efficiency rate of Shengmai group and Isordil group were 86.67% and 70.00% respectively. The effects of improvement ogran CPK, electrocardiogram graph(ECG) and hemorrheology in Shengmai group were markedly higher(P<0.05)than those of Isordil group, but the side effects of Shengmai were significantly lower.Conclusion Shengmai injection was more effective and less side effect in the treatment on AMI in diabetic patients, compared with Isordil injection. The mechanisms of Shengmai injection on AMI include benefits in providing myocardial protection、reducing blood viscosity and improving microcirculation.

关 键 词：参麦注射液 糖尿病 合并症 急性心肌梗死 血液流变学 AMI 治疗方法 

分 类 号：R587.1[医药卫生—内分泌] R542.22[医药卫生—内科学]