包埋于PLGA膜中的BSA海藻酸钙微球的制备及其释放行为  

THE PREPARATION OF PLGA ENCAPSULATED Ca-ALGINATE MICROSPHERES LOADED WITH BSA AND THE RELEASE BEHAVIOR OF BSA

作　　者：张汉威[1] 蔡晴[1] 贝建中[1] 王身国[1] 

机构地区：[1]中国科学院化学研究所高分子物理与化学国家重点实验室,北京100080

出　　处：《高分子学报》2004年第3期454-457,共4页Acta Polymerica Sinica

基　　金：国家重点基础研究资助项目 (项目号 973G1990 5 43 0 6)

摘　　要：Alginate microspheres were formed by coagulation of sodium alginate in CaCl 2 solutions,followed by lyophilization which could create the porous structure.Bovine serum albumin (BSA) was incorporated into the microspheres by mixing BSA with sodium alginate prior to coagulation.The release behavior of BSA from the Ca-alginate microspheres was studied.Further,the alginate microspheres loaded with BSA were embedded in PLGA films by mixing the alginate microspheres with PLGA solutions in order to study the sustained release of BSA from the PLGA film,which is widely used as cell scaffold materials in tissue engineering.The release behavior of BSA from the PLGA film embedded alginate microspheres indicated potential application for keeping the bioactivity of the growth factor.Alginate microspheres were formed by coagulation of sodium alginate in CaCl2 solutions, followed by lyophilization which could create the porous structure. Bovine serum albumin ( BSA ) was incorporated into the microspheres by mixing BSA with sodium alginate prior to coagulation. The release behavior of BSA from the Ca-alginate microspheres was studied. Further, the alginate microspheres loaded with BSA were embedded in PLGA films by mixing the alginate microspheres with PLGA solutions, in order to study the sustained release of BSA from the PLGA film, which is widely used as cell scaffold materials in tissue engineering. The release behavior of BSA from the PLGA film embedded alginate microspheres indicated potential application for keeping the bioactivity of the growth factor.

关 键 词：组织工程 生长因子 聚乳酸羟基乙酸共聚物 制备 生物可降解材料 海藻酸钙微球 牛血清白蛋白 释放行为 

分 类 号：O631[理学—高分子化学]