卡波姆基质帕司烟肼凝胶体外抗结核活性及动物实验的研究  

Activity of Pasiniazid Gel against Mycobacterium Tuberculosis in vitro and Animal Experiment Study

作　　者：李洪敏[1] 王巍[1] 冯端浩[1] 王安生[1] 严黎黎[1] 林明贵[1] 陈宏兵[1] 安慧茹[1] 

机构地区：[1]解放军第三○九医院,北京100091

出　　处：《中国实验动物学报》2004年第2期116-118,共3页Acta Laboratorium Animalis Scientia Sinica

基　　金：全军十五规划课题资助项目 :编号 0 1MA2 17

摘　　要：目的　观察卡波姆凝胶与帕司烟肼联合体外抗结核作用和支气管介入的安全性。方法　手工法、仪器法分别测定卡波姆凝胶与帕司烟肼药物的最小抑菌浓度和最小杀菌浓度及家兔经支气管介入的安全性试验。结果　帕司烟肼的卡波姆凝胶对H37Rv标准株、牛型结核分枝杆菌、草分枝杆菌MIC值分别为 0 1、0 1、0 4mg/L ,MBC值分别为 0 2、0 2和 1 6mg/L ;帕司烟肼的卡波姆凝胶与帕司烟肼单体MIC、MBC值无显著差异 ;家兔动物实验表明该药无任何毒副作用。结论　帕司烟肼凝胶具有与帕司烟肼单体相同的抗结核菌药效 ,卡波姆基质不影响帕司烟肼的抗菌活性 ;Objective To observe effect of pasiniazid gel against Mycobacterium tuberculosis in vitro and the safety of bronchial intervention therapy. Methods\ The MIC and MBC of pasiniazid and pasiniazid gel were measured by handwork and instrument methods,the safety of pasiniazid gel was assessed by bronchial intervention therapy using rabbits as experiment animals. Results\ The MIC of pasiniazid gel to M. tuberculosis H 37 Rv, M. bovis and M. phlei was 0 1, 0 1 and 0 4 mg/L; the MBC of those was 0 2, 0 2 and 1 6 mg/L respectively. The MIC and MBC of pasiniazid gel and pasiniazid had no significant difference without any harmful effect. Conclusion\ The effect of pasiniazid gel and pasiniazid against Mycobacterium tuberculosis was equivalent, and carbomer in the formula did not affect the activity of pasiniazid against Mycobacterium tuberculosis;meanwhile pasiniazid gel which contains carbomer was safe in bronchial intervention therapy.

关 键 词：帕司烟肼 卡波姆凝胶 结核 安全性 动物实验 

分 类 号：R965[医药卫生—药理学] R52[医药卫生—药学]