SM22α:血管平滑肌细胞分化的分子标志  

SM22α: A Maker of Vascular Smooth Muscle Cell Differentiation

作　　者：程云会[1] 韩梅[1] 温进坤[1] 

机构地区：[1]河北医科大学基础医学研究所

出　　处：《细胞生物学杂志》2004年第3期281-284,共4页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(30270499);河北省自然科学基金(303454)

摘　　要：SM22α是一种分化型血管平滑肌细胞(VSMC)的标志基因,编码一种22 kDa的收缩调节蛋白。由于SM22α基因结构短小,表达具有VSMC特异性、调控机制较为清楚,因而被广泛用于VSMC发育分化的研究。利用该基因的表达调控特征,设计可在VSMC中高表达目的蛋白的人工启动子,是心血管病基因治疗的新策略。SM22α is one of vascular smooth muscle cell (VSMC) marker genes, and encodes a 22 kDa contraction-associated protein. SM22α gene is characterized by simple structure and restricted expression in differentiated VSMC. Thus, it has widely been used to study the regulatory mechanisms of VSMC-specific gene expression. On the basis of the features of its expression, recombinant promoters containing SM22α regulatory region have been developed, and serve as a tool for gene therapy to trigger the target protein expression in VSMC.

关 键 词：血管平滑肌细胞 分化 分子标志 SM22α 收缩调节蛋白 

分 类 号：R543[医药卫生—心血管疾病]