亚稀褶黑菇对小白鼠肝肾超微结构的影响  

The Effects of Russula subnigricans Hongo on the Ultrastructure of Mouse Liver and Kidney Cells

作　　者：蒋盛岩[1] 张志光[2] 陈作红[2] 张平[2] 

机构地区：[1]湖南师范大学生命科学学院,中国湖南长沙410081 [2]邵阳学院生物工程系,中国湖南邵阳422004

出　　处：《生命科学研究》2004年第2期150-153,共4页Life Science Research

基　　金：湖南省自然科学基金(02JJY2057)

摘　　要：对小白鼠用亚稀褶黑菇提取液进行毒性试验,测定了亚稀褶黑菇的半致死剂量LD50值;应用透射电镜观察了小白鼠亚稀褶黑菇中毒后的病理变化.结果表明,亚稀褶黑菇的LD50值为2852.1mg/kg,电镜检查发现,亚稀褶黑菇毒素主要损害肾脏,引起肾细胞核核膜肿胀,线粒体肿胀,溶酶体增多,肾细胞坏死.Toxicity tests in mice with the crude extracts of Russula subnigricans Hongo were carried out.The LD50 of the crude extracts of Russula subnigricans Hongo was determined.Transmission electron microscopy was used to observe the histopathologic changes in the poisoned mice.The result showed that the LD50 of the crude extracts of Russula subnigricans Hongo was 2 852.1 mg/kg.Electron microscopy analysis showed significant changes in kidney cells of the poisoned mice,including cell nuclear membrance swelling,mitochondrion cavity and kidney cell necrosis.

关 键 词：亚稀褶黑菇 LD50值 超微结构 

分 类 号：Q255[生物学—细胞生物学]