酪酸梭菌对艰难梭菌感染的防治研究  

The study of preventive and treatment of C.butyricum to toxigenic C.difficile infection

作　　者：傅思武[1] 周殿元[1] 赖卓胜[1] 潘令嘉[1] 姜泊[1] 

机构地区：[1]第一军医大学南方医院全军消化病研究所,广东广州510515

出　　处：《中国微生态学杂志》2004年第3期146-146,148,共2页Chinese Journal of Microecology

基　　金：广州市科研基金课题 (2 0 0 2Z3 EE410 1)

摘　　要：目的 :观察酪酸梭菌对艰难梭菌感染的防治效果。方法 :用艰难梭菌产毒株人工感染BALB/C小鼠 ,感染前后分别用酪酸梭菌进行预防与治疗 ,并检测盲肠内容物细胞毒性和进行肠黏膜病理观察。结果 :酪酸梭菌不能预防艰难梭菌的感染 ,但在艰难梭菌感染后则能明显降低艰难梭菌的产毒力和盲肠黏膜的病理损伤。结论 :酪酸梭菌对小鼠艰难梭菌感染有明显的治疗作用。Objective: To study the mucosal lesions produced after inoculation of C.difficile into the intestine of BALB/C mice,and observe the preventive and treatment effect of C.butyricum to protect mice against intestinal infection caused by toxigenic C.difficile .Methods: C.butyricum were used before and after infection with toxigenic C.difficile in BLAB/c mice.The quantity of cytotoxin produced in cecal and histopathogencal destroy were observed.Results:There were no bacterioprophylaxis using and C.butyricum against infection by toxigenic C.difficile ,but it would reduce the toxin production and enterocolitis of the caecum after the mice were pre-infected with toxigenic C.difficile .Conclusion:Our study confirmed the protective effect of and C.butyricum treatment on BLAB/C mice pre-infecteded with toxigenic C.difficile and showed the this effect was associated with a marked reduction of both toxin A and B production.

关 键 词：酪酸梭菌 艰难梭菌 感染 防治 盲肠内容物 细胞毒性 

分 类 号：R378.8[医药卫生—病原生物学]