肝癌中幽门螺杆菌CagA^+亚型菌株的感染  

Helicobacter pylori CagA^+ subtype strains infection in patients with liver cancer Department of laboratory medicine

作　　者：雷秀霞[1] 陈小辉[1] 徐邦牢[1] 

机构地区：[1]广州市第一人民医院检验科,广东广州510180

出　　处：《中国微生态学杂志》2004年第3期166-166,共1页Chinese Journal of Microecology

摘　　要：目的 :探讨肝癌与H pylori感染的相关性。方法 :采用金标免疫斑点法和酶免疫检测法 (EIA)分别检测 33例肝癌患者及 16 9例普通成人Hp Ab和CagA Hp IgG抗体。 结果 :肝癌组Hp Ab和CagA+ Hp IgG检出率分别为 78 8%和 4 5 5 % ,而普通成人组分别为 5 5 0 %和 2 7 2 % ,经 χ2 检验 ,P <0 0 5 ,差异均有显著性。结论 :肝癌患者由于整体免疫力低下 ,易受H pylori感染。Objective: To investigate the relationship between liver cancer and Helicobacter pylori ( H.pylori ) infection.Methods:Hp-Ab and CagA-Hp-IgG in 33 patients with liver cancer and 169 normal people were respectively measured with colloid gold immunospot and EIA.Results:Positive ratios of Hp-Ab and CagA +-Hp-IgG in liver cancer and control group are 78.8% and 45.5%,55.0% and 27.2%,respectively.There was significance between them by χ 2 test.Conclusion:Patients with liver cancer were liable to be infected by H.pylori .

关 键 词：肝癌 幽门螺杆菌 菌株 感染 抗体 

分 类 号：R378.99[医药卫生—病原生物学] R735.7[医药卫生—基础医学]