肠道菌群失调对小鼠造血因子水平的影响  

Influence of intestinal dysbacteriosis on murine hemopoietic factor

作　　者：张琳[1] 梁庆红[1] 王沛[2] 张亚超[2] 骆金芝[1] 王倩[1] 

机构地区：[1]河北医科大学第三医院儿科,河北石家庄050051 [2]中国人民解放军白求恩军医学院病原教研室,河北石家庄050051

出　　处：《中国微生态学杂志》2004年第3期138-139,共2页Chinese Journal of Microecology

摘　　要：目的 :观察肠道菌群失调后小鼠造血因子水平的变化。方法 :采用抗生素脱污染造成小鼠肠道菌群失调的动物模型 ,用ELISA的方法检测血清白细胞介素 3(IL 3)、粒 巨噬细胞集落刺激因子 (GM CSF)的含量。结果 :菌群失调后小鼠血清IL 3和GM CSF的含量均低于对照组 (P <0 0 1) ;双歧杆菌数量与IL 3和GM CSF含量存在显著正相关。结论 :肠道菌群失调可影响机体造血功能。Obiective:To study the influence of dysbacteriosis on mice's hemopoietic factor.Methods:Animol models were made which have intestinal dysbacteriosis caused by antibiotics.Test the level of IL-3 and GM-CSF by ELISA.Results:Level of IL-3,GM-CSF have obviously decreased when compared with that in the control group( P <0.01).There were marked positive correlations between Bifidobacteria and the level of IL-3,GM-CSF.Conclusion:The results suggest that dysbacteriosis may decrease the hemopoietic function.

关 键 词：肠道 菌群失调 小鼠 造血因子 抗生素 血清 

分 类 号：Q938.15[生物学—微生物学] R378[医药卫生—病原生物学]