多囊卵巢综合征患者子宫内膜增生的临床研究  

Clinical study of endometrium hyperplasia of polycystic orary syndrome

作　　者：王蕊[1] 石月欣[1] 金丽萍[1] 戴吉茹[1] 王越[2] 程北婴[2] 张一光[2] 

机构地区：[1]首都医科大学附属北京天坛医院妇产科,100050 [2]首都医科大学附属北京天坛医院妇产科B超室,100050

出　　处：《北京医学》2004年第2期104-105,共2页Beijing Medical Journal

摘　　要：目的　探讨易发生子宫内膜增生的多囊卵巢综合征 (PCOS)的临床表型特点 ,以指导临床监测与防治。方法　采用前瞻性的研究方法对 76例PCOS者行子宫内膜增生病理、闭经时间、体质指数 (BMI)及胰岛素抵抗和雄激素水平间关系的研究。结果　 76例PCOS者中 1 9例子宫内膜单纯增生 ,3例非典型增生 ;雄激素水平的高低与子宫内膜增生无关 ;胰岛素抵抗、肥胖和闭经≥ 3个月与子宫内膜增生密切相关。结论　PCOS胰岛素抵抗、肥胖、月经类型及年龄与子宫内膜增生有密切关系 ,多囊卵巢综合征患者详细的月经资料及体质指数对确定子宫内膜病变的高危人群有极大的邦助。Objective To investigate the clinical characteristics of endometrium hyperplasia of polycystic orary syndrome(PCOS).Methods This was a prospective study in capital medical science university affiliated Beijing Tiantan Hospital fertility and endocrine clinic.76 patients with PCOS underwent endometrium biopsies.The intermenstrual interval and obesity was analyzed and the level of insulin and sex hormone were measured.The relationship between endometrium hyperplasia with these parameters was assessed by χ 2 test.Results 19 PCOS patients had endometrium hyperplasia.3 patients with PCOS had cytologic atypia.The level of androgen had no relation with endometrium hyperplasia.Insulin resistance,obesity and intermenstrual interval more than 3 months had close relation with endometrium hyperplasia.Conclusions These findings indicate the usefulness of obtaining a detailed menstrual history and usefulness of obtaining the BMI in women with PCOS.Insulin release test should be done in order to identify those at increased risk of endometrium hyperplasia and those who require endometrial biopsy.

关 键 词：多囊卵巢综合征 子宫内膜增生 临床研究 体质指数 病理生理学 胰岛素抵抗 

分 类 号：R711.75[医药卫生—妇产科学]