灰关联聚类法对几种促透剂促透效果的综合评价  

Synthetical evaluation of promoting effect of some kinds of transdermal enhancers with grey relational cluster method

作　　者：王晖[1] 李昕[1] 许碧莲[1] 许卫铭[1] 

机构地区：[1]广东医学院药理学教研室,广东湛江524023

出　　处：《中国中药杂志》2004年第5期417-420,共4页China Journal of Chinese Materia Medica

摘　　要：目的 :对几种促透剂的促透效果进行综合评价。方法 :以双氯芬酸钠为模型药物 ,以氮酮、薄荷醇、冰片、油酸、蛇床子挥发油为促透剂 ,在离体透皮吸收实验装置上进行透皮吸收试验 ,计算累积透过量、渗透速率、稳态流量和滞后时间 ,运用灰关联聚类法评价促透效果。结果 :对双氯芬酸钠的促透作用 ,氮酮、薄荷醇促透效果最好 ,冰片、油酸、蛇床子挥发油次之。结论 :灰关联聚类法可客观地、公正地评价促透剂的促透效果。Objective: Synthetical evaluation of promoting effect of some kinds of transdermal enhancers was carried through. Method: Diclofenac sodium was used as model, and azone and l-menthol and synthetic borneol and olieic acid and essential oil from Cnidium monnieri were used as transdermal enhancers. Transdermal absorption experimentation of diclofenac sodium on the device of penetrating skins in vitro was done. Cumulation of permeation amount and penetrating rates and steady fluxs and lag times were observed, and grey relational cluster method was used to evaluate the promoting effect of some kinds of transdermal enhancers. Result: As for promoting effect on diclofenac sodium, azone and l-menthol were the best, and synthetic borneol and olieic acid ranked behind. Conclusion: Grey relational cluster method can evaluate promoting effect objectively and fairly.

关 键 词：灰关联聚类法 促透剂 促透效果 中药 药剂学 

分 类 号：R283[医药卫生—中药学]