十全大补汤与核桃醌粉针合用对荷瘤小鼠肝脏及免疫功能的影响  

Effect of association of Shiquandabu Tang with Hetaokun on liver and immunity of tumour mouse

作　　者：杜旭[1] 刘璐[1] 张英华[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院,黑龙江哈尔滨150001

出　　处：《中国中药杂志》2004年第5期449-451,共3页China Journal of Chinese Materia Medica

摘　　要：目的 :探讨十全大补汤与核桃醌粉针联合使用对小鼠S180肝脏的保护减毒作用及免疫增强作用的影响。方法 :采用体内移植性肿瘤实验与体外细胞培养相结合的方法 ,观察了单独使用核桃醌粉针和十全大补汤与核桃醌粉针合用对小鼠S180肝脏谷丙转氨酶、单核巨嗜细胞吞噬功能、胸腺指数、脾指数、淋巴细胞转化率等指标的影响 ,并在电镜下观察十全大补汤与核桃醌粉针合用对肝脏的保护作用。结果 :单独使用核桃醌粉针 12 .5mg·kg-1有 73.1%抑瘤作用 ,但使SGPT升高 ,而十全大补汤与核桃醌粉针联合使用可对S180小鼠肝功能起保护作用 ,SGPT与正常对照组相比P >0 .0 5 ;十全大补汤与核桃醌粉针合用组吞噬指数明显提高 ;电镜结果表明 :二药合用组 ,肝细胞变化轻微 ,未见粗面内质网扩张 ;能明显提高荷瘤小鼠的淋巴细胞转化率 ,对T细胞介导的细胞免疫功能有明显促进作用。结论 :提示十全大补汤与核桃醌粉针联合使用 ,发挥了增效减毒作用 ,从而通过增强机体的免疫功能达到整体的抗肿瘤效果。objective: To discuss the effect of the association of Shiquandabutang with Hetaokun on the protection to liver and immunity of tumor mouse S180. Method: Through the comparison between tumor transplanted and tumor cultured completely out of cell body, the effect was investigated, with Hetaokun singly used and Shiquandabutang associated with Hetaokun, on the level of SGPT, licking up function of monocgte macroage, thymus index, spleen index and transform percentage of lymphocyte of the mouse S180. The scanning electron micrographs indicated the protective function of the association of Shiquandabutang with Hetaokun for liver. Result:12.5 mg·kg -1 Hetaokun could obviously restrain the tumor when it was singly used at 73.1%, but it increased SGPT at the same time. The association of Shiquandabutang with Hetaokun could protect liver of the mouse S180. SGPT( P >0.05) was compared with the common ones and the result showed that the association of shiquandabutang with Hetaokun could make K value increase( P >0.01). Through the scanning electron micrographs, association of two medicines was found to change liver cells little and expansion of rough Neizhiwang was not found. Compared with the control group, the immunity of the two tumor mouse groups taking the medicine mentioned above was promoted obviously. Conclusion: The association of Shiquandabutang with Hetaokun can enhance the efficiency and decrease poison of them to body. With the promotion of immunity of the body, the efficiency is enhanced on the whole.

关 键 词：十全大补汤 核桃醌粉针 荷瘤 小鼠 肝脏 免疫功能 免疫增强作用 

分 类 号：R285.5[医药卫生—中药学] R-332[医药卫生—中医学]