2型对氧磷脂酶基因311 Cys/Ser多态性与糖尿病肾病的相关性研究  

Relationship between paraoxonase 2 C311S polymorphism and diabetic nephropathy

作　　者：石红[1] 宁英远[1] 朱秀贞[1] 任建功[1] 陈爱荣[1] 

机构地区：[1]兰州医学院第二附属医院内分泌科,甘肃兰州730030

出　　处：《临床荟萃》2004年第11期623-625,共3页Clinical Focus

摘　　要：目的　探讨 2型对氧磷脂酶 (PON2 )基因 31 1Cys/Ser多态性与 2型糖尿病肾病的相关性及其与血脂的关系。方法　采用聚合酶链式反应 长度片段多态性 (PCR RFLP)技术 ,对 78例 2型糖尿病患者 (其中 2 6例单纯性 2型糖尿病 ,5 2例糖尿病肾病 )和 30例健康对照者 ,PON2基因 31 1Cys/Ser多态性进行检测。 结果　PON2基因31 1Cys/Ser多态性的基因型频率和等位基因频率在 2型糖尿病合并大量蛋白尿组与对照组间差异有统计学意义 ,Ser等位基因在 2型糖尿病合并大量蛋白尿组明显增高。结论　PON2基因 31 1Cys/Ser遗传多态性与中国甘肃地区Objective To determine whether the paraoxonase 2(PON2) gene C311S polymorphism is associated with the pathogenesis of nephropathy in type 2 diabetes mellitus in Chinese population. Methods The PON2 gene C311S polymorphism was detected by polymerase chain reaction (PCR) and apprhopriate restriction enzyme(PCR RFLP). Results The genotype frequency and allele frequency were different between the case and the control group. Conclusion PON2 C311S polymorphism is associated with the pathogenesis of diabetic nephropathy.

关 键 词：对氧磷 基因 多态性 糖尿病 非胰岛素依赖型 糖尿病肾病 

分 类 号：R587.1[医药卫生—内分泌]