CD_(4)、CD_(8)、CD_(95)在急性胰腺炎中作用的中西医结合临床研究  

The Clinical Study of CD_4、CD_8、CD_(95)in the Treatment with Integrated Western and Chinese Medicine in Acute Pancreatitis

作　　者：唐文富[1] 陈光远[1] 张颖[1] 巫刚[1] 夏庆[1] 蒋俊明[1] 

机构地区：[1]四川大学华西医院中西医结合科,四川成都610041

出　　处：《华西医学》2004年第2期209-210,共2页West China Medical Journal

基　　金：四川省中医药管理局资助项目(H0025)

摘　　要：目的 :初步探讨急性胰腺炎 (AP)患者外周CD4+T、CD8+T、CD95+T的临床意义。方法 :选择 35例AP患者 ,利用流式细胞仪 (FCM)检测中西医结合治疗过程中外周CD4+T、CD8+T、CD95+T的水平。结果 :①CD4+T、CD4+T/CD8+T于早期降低明显 ,肝脾湿热 (GRSR)组、脾胃实热 (PWSR)组更为显著 ,经中西医结合治疗后恢复。②CD8+T在各组患者中均无明显变化。③CD95+T肝脾气滞 (GPQZ)组、GPSR组各时点均明显升高 (P <0 0 1,P <0 0 5 ) ;PWSR组早期无变化 ,第四天后明显升高 (P <0 0 5 ) ,但升高幅度明显低于前者。结论 :①AP患者早期细胞免疫功能显著降低 ,GPSR组和PWSR组更明显。②CD95与病情轻重成反变关系。③热毒内盛可能使机体CD95功能减弱或表达降低 ,机体出现明显的SIRS过程 ,益活清下 (YHQX)法使其表达升高而下调免疫炎性反应。Objective:To study the clinical signifcance of CD 4+T?CD 8+T?CD 95 +T in acute pancreatitis.Methods:The peripheral CD 4+T?CD 8+T?CD 95 +T were determined by flow cytometry in 35 acute pancreatitis patients treated with integrated TCM and western medicine and 30 normal controls.Results:1.The lymphocyte surface marker antigen fo CD 4+T and the ratios of CD 4+T/CD 8+T decreased significantly(P<0.01,P<0.05)in acute phase of AP,especialy in GPSR?PWSR groups;2.CD 8+T have no alternations in all groups;3.The lymphocyte surface marker antigne CD 95 +T increased significantly in patients with AP(P<0.05),especially in GPQZ group.Conclusions:1.The cell immune function decreased significantly in acute phase of aacute pancreatitis,especially in GPSR and PWSR groups.2.CD 95 +T was a beneficial factor,which is inverse to the severity of AP.3.CD 95 +T could down-regulate the inflammatory response in AP,which affect the pathophysiologic process of SIRS.4.Retention of damp heat is perhaps the cause of decreasing of CD 95 and its low expression with obvious course of SIRS;Treatment of YHQX with chinese herbs could increase the expression of CD 95 and attenuate the course of SIRS.

关 键 词：CD_(4) CD_(8) CD_(95) 急性胰腺炎 免疫炎性反应 

分 类 号：R65751[医药卫生—外科学]