锌、钼对亚急性镉中毒肾损伤保护作用的比较  

Comparison of protective effect of zinc and molybdenum on subacute renal damage induced by cadmium

作　　者：王凤清[1] 徐美华[1] 连微峰 连祥霖[3] 

机构地区：[1]福建医科大学附属第一医院检验科,福州350005 [2]福州市铁路中心医院,350007 [3]福建医科大学公共卫生学院,福州350004

出　　处：《国外医学（临床生物化学与检验学分册）》2004年第3期207-208,共2页Foreign Medical Sciences(section of Clinical Biochemistry and Laboratory Medicine

摘　　要：目的　探讨微量元素对亚急性镉中毒肾损伤的保护作用。方法　用氯化镉制备大鼠亚急性镉中毒模型 ,使其发生明显的肾损伤。经锌、钼预处理后再给予同剂量氯化镉 ,比较镉组、锌镉组、钼镉组及对照组各项肾功能指标。结果　锌镉组尿量无明显变化 ,尿镉排泄量明显减少 ,而肾镉蓄积量明显增加。钼镉组尿量和尿镉明显增高 ,而肾镉蓄积量减少 ;肾功能两组均有不同程度改善。结论　锌、钼对亚急性镉中毒肾损伤均有保护作用 ,其效果钼比锌好 。Objective To study the protective effect of trace elements on subacute toxic renal damage induced by cadmium.Methods Subacute cadmium poisoning model was prepared with cadmium chloride in rats to induce obvious renal damage.After pretreated with zinc and molybdenum,the rats were given the same dose of cadmium chloride.The renal function was determined in cadmium group,zinc and cadmium group,and molybdenum and cadmium group.Results The urine vulume didn′t change significantly,but cadmium excreted by urine decreased,cadmium level in kidnry increased markedly in zinc and cadmium group.By contrast,in molybdenum and cadmium group,the urine vulume and urine cadmium increased markedly,cadmium level in kidnry decreased significantly.Ronal function in two groups was ameliorated to a different extent.Conclusions Zinc and molybdenum might have protective effect on subacute toxic renal damage induced by cadmium.This provides a new way in prophylaxis and treatment of cadmium poisoning.

关 键 词：锌 钼 亚急性镉中毒 肾损伤 生物学活性 

分 类 号：R96[医药卫生—药理学]