高剂量率后装^(192)Ir源剂量测试研究进展  

Dosimetric advancement of high-dose-rate after-loading ^(192)Ir source

作　　者：张书旭 李文华[2] 徐海荣[2] 

机构地区：[1]广州市肿瘤医院放疗中心,510095 [2]第一军医大学生物医学工程系,广州510515

出　　处：《国外医学（放射医学核医学分册）》2004年第3期135-138,共4页Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)

基　　金：广东省科技计划资助项目(C30601);广东省自然科学基金资助项目(37065)

摘　　要：现代后装治疗大多采用HDR(高剂量率)微型192Ir源,其近源区剂量特性常用针点电离室、热释光剂量计测量,但ESR(电子自旋共振)胶片法测量的空间分辨率更高,可达156μm,而蒙特卡罗光子输运模拟方法是衡量测量准确度的金标准。用热释光剂量计进行直肠内剂量测量是预测直肠并发症发生率的良好指针。慢感光胶片测量192Ir源二维剂量分布精度可达1%,用基于MR(核磁共振)的凝胶剂量计测量192Ir源三维剂量分布准确度可达2.5%、空间分辨率达1.56mm,光学体层成像凝胶剂量计测量三维剂量分布具有独特的优势。High-dose-rate (HDR) 192Ir source is a nuclide commonly used in the brachytherapy system. The basic dosimetry data of the near source area is usually measured by pin ion chambers or TLD techniques, but these methods have a lower spatial resolution than Electron spin resonance (ESR) dosimetry which has a spatial resolution of 156μm, and the Monte Carlo photon transport simulations are taken as the golden standard of those measures. The precision in two-dimensional dose distribution measured by GafChromic film is reported to be 1.0%. In vivo dosimetry using TLD during HDR intracavitary after-loading brachytherapy is a good predictor of late rectal complications. The accuracy of magnetic resonance imaging (MRI) Fricke-gel dosimetry for three-dimensional dose distribution is about 2.5% with a spatial resolution of 1.56mm. The optical computed tomography polymer gel dosimetry has a unique advance than MRI gel dosimetry.

关 键 词：高剂量率:后装治疗 ^192IR源 三维剂量 

分 类 号：R144.1[医药卫生—公共卫生与预防医学]