苏木蓝化学成分的研究  

Studies on chemical constituents of Indigofera carlesii

作　　者：苏艳芳[1] 张新鑫[1] 杨静[1] 郭增军[2] 吕居娴[2] 果德安[3] 

机构地区：[1]天津大学药学院,天津300072 [2]西安交通大学药学院,陕西西安710061 [3]北京大学药学院,北京100083

出　　处：《中草药》2004年第6期608-611,共4页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助 ( 3 0 2 0 0 0 2 4)

摘　　要：目的　研究山豆根代用品的主要来源植物之一——豆科木蓝属植物苏木蓝 Indigofera carlesii的化学成分 ,寻找其活性成分和 /或毒性成分。方法　运用溶剂萃取、硅胶柱色谱、重结晶分离纯化 ,根据化合物的光谱数据鉴定其结构。结果　从苏木蓝的根中分离得到 9个化合物 ,分别鉴定为 3-硝基丙酸 ( ) ,coronarian( ) ,corollin( ) ,羽扇豆醇 ( ) ,白桦脂酸 ( ) ,β-谷甾醇 ( ) ,胡萝卜苷 ( )、豆甾醇 - 3- O-葡萄糖苷 ( ) ,琥珀酸 ( )。结论　化合物 ～ 和 为首次从苏木蓝分离得到 ,化合物 、 和 ～ 为首次从木蓝属植物中分离得到 ;化合物 ～Object To study the chemical constituents of Indigofera carlesii Craib (Leguminosae), a main substitute for traditional Chinese drug 'Shandougen' and to seek its active and/or toxic principles. Methods Compounds were separated and purified by solvent extraction, silica gel column chromatography and re-crystallization. Their structures were elucidated on the basis of their spectral data. Results Nine compounds were isolated and identified from the roots of I. carlesii: 3-nitropropionic acid (Ⅰ), coronarian (Ⅱ), corollin (Ⅲ), lupeol (Ⅳ), betulinic acid (Ⅴ), β-sitosterol (Ⅵ), daucosterol (Ⅶ), stigmasterol-3-O-glucopyranoside (Ⅷ), and succinic acid (Ⅸ). Conclusion Compounds Ⅰ-Ⅲ, and Ⅵ are first isolated from I. carlesii, and compounds Ⅳ, Ⅴ and Ⅶ- Ⅸ are obtained form the plants of Indigofera Linn. for the first time. Compounds Ⅰ-Ⅲ can account for the toxicity of I. carlesii.

关 键 词：苏木蓝 3-硝基丙酸 3-硝基丙酰基葡萄糖 三萜类化合物 

分 类 号：R284.1[医药卫生—中药学]