酒精中毒患者血清中肝细胞再生因子水平的测定及其意义  

Measurement of hepatocyte growth factor in the blood serum of alcoholic intoxication patients and its signification

作　　者：王玉书[1] 李长鹤 金哲洙[3] 孙文霞[1] 姜美子[1] 朴虎男[1] 

机构地区：[1]延边大学医学院附属医院神经内科,吉林延吉133000 [2]延边肿瘤医院普通外科,吉林延吉133000 [3]延边大学医学院生物免疫研究所,吉林延吉133000

出　　处：《临床肝胆病杂志》2004年第3期159-160,共2页Journal of Clinical Hepatology

摘　　要：探讨酒精中毒患者血清中肝细胞再生因子水平的变化及其意义。应用组织细胞培养法及同位素标记技术对 30例酒精中毒患者和 30例健康对照组血清中肝细胞再生因子水平进行测定。急性酒精中毒患者伴有肝功能异常者血清中肝细胞再生因子水平高于慢性酒精中毒 (P <0 0 5 ) ,并显著高于正常对照组 (P <0 0 1)。为估计酒精中毒患者的肝损伤程度提供参考价值。This study was done to investigate the change of hepatocyte growth factor in alcoholic intoxication patients and its signification. Tissue-cell culture and isotopelabeled technique were used to determine the difference of the hepatocyte growth factor in the blood serum between 30-alcoholic intoxication patients and 30-healthy control groups. The hepatocyte growth factor in the blood serum of acute alcoholic intoxication patients with severe hepatic injury was higher than that of chronic alcoholic intoxication patients with gentle hepatic injury (P<0.05),and it was significantly higher than that of control groups (P<0.01). Above results can provide reference criteria for estimating the level of hepatic injury in the alcoholic intoxication patients.

关 键 词：酒精中毒 血清 肝细胞再生因子 测定 肝损伤 

分 类 号：R5956[医药卫生—内科学]