急性淋巴细胞白血病患儿体内细胞因子变化的意义研究  

The study of cytokines in the body of patients with acute lymphocytic leukemia

作　　者：盛光耀[1] 李玲[2] 邹湘[1] 赵晓明[1] 

机构地区：[1]郑州大学第一附属医院儿内科,河南郑州450052 [2]郑州大学第三附属医院儿内科,河南郑州450052

出　　处：《河南医学研究》2004年第2期144-145,共2页Henan Medical Research

摘　　要：目的 :探讨IL 12在儿童急性淋巴细胞白血病 (acutelymphocyticleukemia ,ALL)发病机制中的作用及临床意义。方法 :采用ELISA法检测 47例初治ALL及 2 0例完全缓解患儿血清中IL 12的水平。结果 :①MIC分型 47例ALL患儿中B ALL 3 9例 ,T ALL 8例。②ALL患儿血清中IL 12浓度较对照组和完全缓解组显著降低 (P <0 0 5 )。B ALL和T ALL ,正常对照和完全缓解组之间差异均无显著性 (P >0 0 5 )。结论 :ALL患儿体内可能存在TH1/TH 2样细胞因子产生的失平衡状态 ,这可能是ALL发病中的重要机制之一。Objective:To study the clinical significance of serum interleukin-12 level in patients with acute lymphocytic leukemia(ALL).Methods:Serum level of interleukin-12 was measured in 47 patients with ALL by Sandwich enzyme linked in immunosorbent assay(ELISA).Results:①There were 39 patients with B-ALL and 8 patients with T-ALL by morthology immunology cytogenetics(MIC) standard.②The level of IL-12 in serum of ALL children was lower than that in control group and complete recession(CR) group,the difference was significant (P< 0.05).There were no significantly difference between B-ALL and T-ALL,control group and CR group(P> 0.05).Conclusion: The maladjusted state of TH1/TH2 cytokines may exist in ALL children.This may be one of the important mechanism in the occurence of ALL.

关 键 词：急性淋巴细胞白血病 细胞因子 肿瘤免疫 IL-12 

分 类 号：R725.5[医药卫生—儿科] R733.7[医药卫生—临床医学]