SiO_2溶胶凝胶固定的扑尔敏电极  

A Chlorphenamine Maleate Electrode Immobilized by SiO_2 Sol-Gel

作　　者：黄婷婷[1] 周建华[1] 彭谦[1] 梁汝萍[1] 蔡沛祥[1] 

机构地区：[1]中山大学化学与化学工程学院,广州510275

出　　处：《应用化学》2004年第7期673-677,共5页Chinese Journal of Applied Chemistry

基　　金：广东省自然科学基金 ( 0 1110 5 );中山大学开放实验室基金资

摘　　要：以包埋有四苯硼 扑尔敏缔合物的SiO2 溶胶凝胶修饰铂盘电极 ,构成电位型扑尔敏药物电极。以铁氰化钾作为氧化还原探针 ,采用循环伏安法 (CV)对电极各种修饰状态进行了表征。该电极对扑尔敏的Nernst响应范围为 5 2× 10 -7～ 8 0× 10 -4mol/L ,斜率为 5 78× 10 -2 V/ pC ,检出限为 2 8× 10 -7mol/L ,相关系数r =0 999,pH值适用范围为 3 0～ 8 5。A chlorphenamine maleate(CPM) electrode of potentiometric type has been prepared by drip- coating the surface of disk platinum electrode with SiO 2 sol-gel containing chlorphenamine tetraphenylborate ion-pair complex as sensing agent. Experimental results indicate the good electrode performances. The range of linear response is 5.2×10 -7～8.0×10 -4 mol/L with detection limit of 2.8×10 -7 mol/L, the slope is 5.78×10 -2 V/pC and the correlation coefficient 0.999. The electrode can be used at pH range of 3.0～8.5 and exhibits an excellent stability and reproducibility. The determination of chlorphenamine maleate in pharmaceuticals also gives satisfactory results. The electrode shows good properties when it is applied to urine sample and gives a good excretion curve of chlorphenamine maleate.

关 键 词：四苯硼-扑尔敏缔合物 扑尔敏药物电极 SiO2溶胶凝胶 

分 类 号：O657.12[理学—分析化学]