超临界CO_2在水杨酸/聚ε-己内酯缓释体制备中的应用  

Application of Supercritical CO_ 2 in Preparation of Salicylic Acid Poly(ε-caprolactone) Controlled Releasing System

作　　者：许群[1] 后振中[1] 张世杰[1] 彭琦[1] 任现文[1] 

机构地区：[1]郑州大学材料工程学院,郑州450052

出　　处：《应用化学》2004年第7期751-753,共3页Chinese Journal of Applied Chemistry

摘　　要：Salicylic acid as a drug carrying agent was intercalated into microporous poly(ε-caprolactone)(PCL) and PCL resin particles using supercritical CO 2 as solvent. The drug releasing currves in 95% ethanol solution for open-hole PCL and close-hole PCL particles have been obtained and the releasing half-life(t 1/2) for both systems were calculated to be 35 h and 57 h, respectively. The latter appears more preferable.Salicylic acid as a drug carrying agent was intercalated into microporous poly(ε-caprolactone)(PCL) and PCL resin particles using supercritical CO 2 as solvent. The drug releasing currves in 95% ethanol solution for open-hole PCL and close-hole PCL particles have been obtained and the releasing half-life(t 1/2) for both systems were calculated to be 35 h and 57 h, respectively. The latter appears more preferable.

关 键 词：超临界CO2 水杨酸 聚Ε-己内酯 缓释 

分 类 号：O648.16[理学—物理化学]