α-溴代邻氯苯乙酸拆分过程中的自消旋现象研究  

Spontaneous Racemization of α-Bromo-(o-chloro)phenylacetic Acid During the Resolving Process

作　　者：何佺[1] 彭阳峰[2] 

机构地区：[1]宁波高等专科学校化工系,浙江宁波315016 [2]华东理工大学化工学院,上海200237

出　　处：《合成化学》2004年第4期399-401,J005,共4页Chinese Journal of Synthetic Chemistry

摘　　要：以S (- ) α 苯乙胺 [S (- ) PEA]为拆分剂 ,对消旋的α 溴代邻氯苯乙酸 (BrA)进行拆分 ,在实验过程中发现 ,R BrA或S BrA容易发生自消旋。Bromo-(o-chloro)phenylacetic acid(BrA) can be resolved with optically active α-phenylethylamine(PEA) as resolving agent. Both BrA and BrA·PEA are easy to be racemized spontaneously. The racemization mechanism of BrA and BrA·PEA in solution or its solid state has been studied.

关 键 词：α-溴代邻氯苯乙酸 Α-苯乙胺 拆分 消旋 自消旋 

分 类 号：O621.14[理学—有机化学]