瘦素、神经肽Y与多囊卵巢综合征关系的研究  

Study of Leptin and Neuropeptide Y on Pathogenesis in Women With Polycystic Ovary Syndrome

作　　者：杨业洲[1] 李蓬秋[1] 岳军[1] 陈廉[1] 符本琪[1] 

机构地区：[1]四川省人民医院,四川成都610072

出　　处：《实用妇产科杂志》2004年第3期161-163,共3页Journal of Practical Obstetrics and Gynecology

摘　　要：目的 :探讨瘦素和神经肽Y(NPY)在多囊卵巢综合征 (PCOS)发病中的作用。方法 :测定 15 3例PCOS患者和6 7例对照组患者的身高体重指数 (BMI)、脂肪百分率、腰围 /臀围比值 (WHR)、E2 、P、T、PRL、LH、FSH、口服葡萄糖耐量试验 (OGTT)、血糖、胰岛素、C肽、瘦素和NPY ,应用Pearson相关分析法分析瘦素或NPY与各指标之间的相互关系 ,对与BMI、脂肪百分率、瘦素和NPY呈显著相关的各指标进一步进行Partial相关分析。结果 :PCOS患者的血清瘦素水平为17.9± 1.8ng/L ,NPY血清水平为 2 97.7± 9.8μg/L ,均明显高于对照组的血清瘦素 (10 .6± 2 .1ng/L)和NPY水平 (15 3.5±13.4 μg/L) (P <0 .0 1,P <0 .0 5 )。Pearson相关分析发现 ,BMI、WHR、脂肪百分率、OGTT、空腹血糖、胰岛素、C -肽值、OGTT胰岛素曲线下面积等与瘦素或NPY在PCOS组和对照组都呈显著正相关 ,PCOS组的相关系数高于对照组。两组的平均年龄、FSH、E2 、LH、LH/FSH、T、PRL、OGTT血糖、C -肽曲线下面积均与瘦素或NPY无显著相关关系。BMI、脂肪百分率及OGTT胰岛素曲线下面积均与PCOS组的血清瘦素和NPY明显高于对照组的现象有关。结论 :高NPY和瘦素水平与PCOS患者的肥胖和胰岛素抵抗密切相关 ,可能参与了PCOS的发生。Objective:To study the role of leptin and neuropeptide Y on pathogenesis in women with polycystic ovary syndrome(PCOS).Methods:Body mass index(BMI)? fat percentage?waist to hip ratio(WHR)?serum E 2?P?T?prolactin(PRL)? FSH?LH?leptin?neuropeptide Y, fasting glucose?insulin?C-peptide concentration, and oral glucose tolerance test(OGTT) were assessed in 153 PCOS women and 67 normal control women .The correlation of the aboved parameters were analyzed by Pearson method ,if there exised significant positive relations, further analyses were done by Partial relatives analysis. Results:Leptin level and neuropeptide Y concentration of patients with PCOS was 17.9±1.8 ng/L and 297.7±9.8 μg/L, respectively that were significant higher than those in normal women whose were 10.6+2.1 ng/L and 153.5±13.4 μg/L that respectively(P<0.01,P<0.05). There were significant positive correlation between MBI? fat percentage?WHR?fasting glucose?insulin?C-peptide?area under curve of insulin during OGTT and serum leptin or neuropeptide Y in PCOS and control women by Pearson analysis.There was no association between mean age,FSH.E 2,LH,LH/FSH ratio,T?PRL?OGTT area under curve of c-peptide and serum leptin or neuropeptide Y in two qroups.The higher leptin and neuropeptide Y concentration in women with PCOS might caused by higher BMI? fat percentage and area under curve of insulin during OGTT. Conclusions:The higher levels of Leptin and neuropetide Y are closely related with obesity and insulin resistance in women with polycystic ovary syndrome and probably participate together in the pathogenesis of PCOS.

关 键 词：多囊卵巢综合征 瘦素 神经肽Y 

分 类 号：R711.75[医药卫生—妇产科学]