CD44s、CD44v6在子宫内膜异位症在位和异位内膜组织中的表达  

Expression of CD44s and CD44v6 in Eutopic and Eutopic Endometrium of Endometriosis and Endometriotic Tissue

作　　者：周凯[1] 何福仙[2] 张吟雪[1] 吴秀玲[1] 郑飞云[1] 

机构地区：[1]温州医学院附属第一医院,浙江温州325000 [2]华中科技大学同济医院,湖北武汉430030

出　　处：《实用妇产科杂志》2004年第3期164-166,F010,共4页Journal of Practical Obstetrics and Gynecology

摘　　要：目的 :探讨细胞粘附分子CD4 4s、CD4 4v6与子宫内膜异位症发病的关系。方法 :采用光镜和SP免疫组化方法对 2 0例正常内膜、2 0例子宫内膜异位症 (EM)在位内膜和对应的卵巢异位子宫内膜和 15例子宫内膜腺癌组织进行病理组织学观察和CD4 4s、CD4 4v6表达的检测。结果 :①正常子宫内膜的分泌期腺上皮细胞均表达CD4 4s、CD4 4v6 ,增生期两者均不表达 ;间质细胞不管增生期还是分泌期只表达CD4 4s。②EM分泌期在位内膜腺上皮细胞CD4 4s表达显著高于同期对照组 ,在位和异位内膜腺上皮、子宫内膜腺癌细胞CD4 4v6的表达均显著高于对照组。部分增生期在位内膜和异位内膜的腺上皮也出现CD4 4s、CD4 4v6的表达。结论 :①CD4 4s、CD4 4v6在正常子宫内膜腺上皮中的表达呈周期性改变 ,提示可能与细胞分化有关。②EM组在位和异位内膜CD4 4s、CD4Objective:To explore the relationship between cellular adhesion molecule CD44s?CD44v6 and pathogenesis of endometriosis.Methods:Immunohistochemical technique was adopted with light-microscopy for detecting CD44s and CD44v6 expression in 20 cases of normal endometriums (Control group: C) and 20 cases of eutopic endometrium with endometriosis(EMU) and corresponding ovarian ectopic endometrium(EMC), and 15 cases of endometrial adenocarcinoma. Results:①Positive expression for CD44s and CD44v6 was observed in a secretory pattern and negative in a proliferative pattern of normal glandular epithelial cells, whereas the stroma cell was only positive for CD44s in both proliferative and secretory patterns. ②The expression of CD44s in glandular epithelium of EMU in secretory pattern was significantly higher than that in C, the expression of CD44v6 in glandular epithelium of EMU and EMC in secretory pattern and in CA was all significantly higher than that in C. In some glandular epithelium of EMU and EMC in proliferative pattern also exhibited the expression of CD44s and CD44v6.Conclusions: ①The expression of CD44s and CD44v6 in glandular epithelium of normal group showed a cyclic change following to ovarian hormonal regulation, that means its expression of CD44 may be correlated with the secretory differentiation of endometrial glands. ② The abnormal expression of CD44 isoforms in endometriotic tissue may play an important role in the pathophysiology of endometriosis.

关 键 词：子宫内膜异位症 细胞粘附分子 CD44 免疫组织化学 

分 类 号：R711.71[医药卫生—妇产科学]