轻中度高血压患者早期肾损害与脉压的关系  

Relationship between the early renal injury and the pulse pressure in hypertension patients

作　　者：曹国良[1] 乔永芳[1] 

机构地区：[1]上海第二医科大学附属宝钢医院,上海201900

出　　处：《心血管康复医学杂志》2004年第3期214-216,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨轻中度高血压患者早期肾损害与脉压、脉压指数的关系。方法:100例轻中度高血压患者检测血、尿β_2-MG及尿白蛋白,同时计算脉压、脉压指数,根据有、无肾损害分组比较脉压、脉压指数差异;根据脉压、脉压指数分组比较血、尿β_2-MG及尿白蛋白含量。结果:高血压患者脉压>60mmHg组血β_2-MG 4.24±1.18 mg/L,尿β_2-MG 1.17±0.88 mg/L,尿白蛋白24.8±7.3 mg/L;脉压<60mmHg组血β_2-MG 2.56±1.34 mg/L,尿β_2-MG 0.42±0.10 mg/L,尿白蛋白18.3±4.7 mg/L,两组比较 P<0.05;脉压指数>0.6组血β_2-MG 4.56±1.23 mg/L,尿β_2-MG 1.09±0.56 mg/L,尿白蛋白25.3±4.5 mg/L;脉压指数<0.6组血β_2-MG2.49±1.09 mg/L,尿β_2-MG0.33±0.09 mg/L,尿白蛋白17.4±3.3 mg/L,两组比较P<0.05。结论:高血压患者随着PP和PPI的增大而出现肾损害的加重。Objective: To evaluate the relationship between the early renal injury in hypertension patients and the pulse pressure, the pulse pressure index. Methods: The pulse pressure (PP) and the pulse pressure index (PPI) in 100 patients with mid to moderate essential hypertension were calculated and the serum β_2-microglobulin (β_2-MG), the urine β_2-MG、albumin were detected. Results: The serum β_2-MG and the urine β_2-MG. albumin in patients with whose pulse pressure was>60 mmHg were higher than those of pulse pressure was<60 mmHg (P<0.05); The serum β_2- MG and the urine β_2-MG. albumin in patients with whose pulse pressure index was>0.6 were higher than those of pulse pressure index was<0.6 (P<0.05). Conclusion: The renal injury is more severe in hypertension patients with whose pulse pressure and pulse pressure index is higher.

关 键 词：轻中度高血压 早期肾损害 脉压 脉压指数 检测 血Β2-MG 尿白蛋白 尿Β2-MG 

分 类 号：R544.1[医药卫生—心血管疾病] R692[医药卫生—内科学]