氯沙坦治疗充血性心力衰竭并高尿酸血症的临床研究  

Therapeutic effect of losantan on congestive heart failure complicated with hyperuricemia

作　　者：周明 

机构地区：[1]东芜市通喾医院,广东东莞523176

出　　处：《心血管康复医学杂志》2004年第3期227-229,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨氯沙坦治疗充血性心力衰竭(CHF)合并高尿酸血症患者的临床疗效及心功能改善与血尿酸水平的关系。方法:63例CHF合并高尿酸血症患者随机被分为两组,在强心、利尿的基础上,氯沙坦组给予氯沙坦25～75mg口服,每日1次;苯那普利组给予苯那普利5～15mg口服,每日1次,疗程8周,用药开始及用药8周末分别作血尿酸含量及血生化检查,用超声心动图评定左室收缩功能变化。结果:经治疗两组患者心功能及左室射血分数均明显改善(P<0.01);血尿酸水平亦均明显降低(P<0.01);而氯沙坦组较苯那普利组降低更显著(P<0.05);氯沙坦组治疗期间未出现严重不良反应。结论:对CHF合并高尿酸血症患者的治疗,氯沙坦比苯那普利更有效。Objective: To study the therapeutic effect of Losantan on congestive heart failure (CHF) complicated with hyperuricemia and correlation between heart function and level of serum uric acid. Methods: A total of 63 CHF patients complicated with hyperuricemia randomly divided into two groups. Based therapy of cardiac stimulant and diuresis, the Losartan group patients treat with Losartan (35～75 mg/d), Benazepril group patients treated with Benazepril (5～15mg/d), ×8 weeks. Serum uric acid, blood biochemical index and LVEF were detected before and 8 week after treatment. Results: Heart function and LVEP of two groups were significantly ameliorated (P<0.05), then the level of serum uric acid significantly decreased (P<0.01), but level of serum uric acid of Losartan group decreased more than that of Benazepril group (P<0.05). Conclusion: Losantan is more effect than Benazepril for CHF patient complicated with hyperuricemia.

关 键 词：氯沙坦 药物治疗 充血性心力衰竭 并发症 高尿酸血症 心功能 

分 类 号：R541.61[医药卫生—心血管疾病] R589.3[医药卫生—内科学]