1997～2001年耐甲氧西林葡萄球菌临床分离率及耐药性分析  

Analysis on the isolation and resistance of methicillin-resistant Staphylococcus from 1997 to 2001 in hospital

作　　者：吕火祥[1] 沈蓓琼[1] 潘立勇[1] 胡庆丰[1] 刘建栋[1] 

机构地区：[1]浙江省人民医院,浙江杭州310014

出　　处：《检验医学》2004年第3期220-224,共5页Laboratory Medicine

摘　　要：目的　回顾分析耐甲氧西林葡萄球菌 (MRS)在临床的分离与耐药情况 ,了解本地区此类细菌的分离及耐药趋势。方法　统计分析 5年来医院内MRS的分离及耐药情况。结果　MRS从 1997年 5种 (5 1株 )增至2 0 0 1年 13种 (345株 )。 1997～ 2 0 0 1年 ,耐甲氧西林的金黄色葡萄球菌 (MRSA)与耐甲氧西林凝固酶阴性葡萄球菌 (MRS CN)对万古霉素耐药率为 0 ,对复方磺胺甲唑的耐药率分别为 6 .2 %～ 2 1.1%、2 2 .4 %～ 36 .4 % ;对其他种类抗生素耐药率均在 5 5 %以上 ;耐药率增长最快的为环丙沙星 :MRSA 5 1.4 %～ 88.6 % ;MRS CN5 6 .3%～ 88.8%。mecA基因检出率 :MRSA 98.8%～ 10 0 .0 % ;MRS CN 93.8%～ 99.0 %。结论　MRS在临床的分离率逐渐增加 ,其对非 β 内酰胺类抗生素的耐药率也在不断增加。临床在治疗葡萄球菌引起的感染时 。Objective To review and analyse the data of the isolation and resistance of methicillin resistant Staphylococcus (MRS) in our hospital from 1997 to 2001, in order to show the tendency of these aspects of the MRS in that area. Methods The data of isolation and resistance of MRS in the last five years were analysed by statistical method. Results The spp of MRS were 5 in 1997 and increased to 13 in 2001. The strains of MRS were grown up from 51 in 1997 to 345 in 2001. The resistance of MRSA and MRS CN to the 7 types of non β lactams, except the vancomycin was zero, the lowest was sulfamethoxazole trimethoprim with 6.2% to 21.1%, and 22.4% to 36.4%, respectively, and the others were over 55%. The resistance rate of ciprofloxacin increased most rapidly: MRSA from 51.4% to 88.6%, MRS CN from 56.3% to 88.8%. About mecA gene:there were 98.8% to 100.0% positive in MRSA and 93.8% to 99.0% in MRS CN. Conclusions The isolation of MRS in hosptal is increasing, and the resistance of non β lactams is increasing also. It is important to prepare a good precept of treatment for patients with infection before confirmation of isolation of MRS.

关 键 词：1997-2001年 耐甲氧西林葡萄球菌 临床分离率 耐药性 MRS 菌株 

分 类 号：R378.1[医药卫生—病原生物学]