健骨颗粒对去卵巢骨质疏松模型大鼠骨质量的影响  

Effect of Jiangu Granule on Quality of Bone in Model Rats with Osteoporosis Induced by Ovariectomy

作　　者：林燕萍[1] 周瑞祥[2] 郭世明[1] 黄美雅[1] 张安桢[1] 

机构地区：[1]福建中医学院骨伤系,福州350003 [2]福建医科大学基础医学院

出　　处：《中国中西医结合杂志》2004年第5期431-434,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：福建省自然科学基金项目(No.C9830001);福建省教育厅科技三项经费课题(No.K02083)

摘　　要：目的 探讨健骨颗粒对骨质疏松模型大鼠骨质量的影响。方法 运用切除大鼠卵巢方法建立去卵巢骨质疏松症模型,应用双能X线骨密度仪测定骨密度;运用不脱钙骨切片、甲苯胺蓝染色观察胫骨上端组织结构并作形态计量;运用光测弹性仪加力架测定第1腰椎压缩强度极限和弹性模量,以及股骨弯曲破坏荷载。结果 健骨颗粒能有效提高模型大鼠骨密度、骨小梁面积和骨皮质厚度/髓腔直径比值,提高椎体骨压缩强度极限和股骨弯曲破坏荷载。结论 健骨颗粒在增加骨质疏松模型大鼠骨密度的同时,能有效改善骨组织的结构状况,提高骨骼生物力学性能,提高骨质量。To study the effect of Jiangu granule (JGG) on quality of bone in model rats with osteoporosis. Methods Osteoporosis model was established by means of ovariectomy. Bone mineral density (BMD) was measured with dual energy X-ray densitometry. Osseous tissue structure of upper tibia was observed by ono-decalci-fied section and toluidine blue staining, and morphometry was carried out. Compressive strength limit and elastic modulus of first lumbar vertebrae, and bend load of femur were measured by light-based elastometer. Results JGG can significantly increase BMD, area of trabecula and thickness of bone cortex/diameter of marrow cavity ratio of model rats, to elevate the compressive strength limit of vertebrae and bend load of femur. Conclusion JGG could increase BMD of osteoporosis model rats, and also could effectively improve the structure of osseous tissue, biomechanical property of bone and enhance the overall quality of bone.

关 键 词：健骨颗粒 去卵巢大鼠 骨质疏松 生物力学 骨质量 

分 类 号：R285[医药卫生—中药学]