运动与活性维生素D联合作用对老年骨质疏松症患者骨量的影响  

Effect of exercises plus active vitamin D treatment on the bone mass of the elderly patients with osteoporosis

作　　者：夏秦[1] 汪红兵[1] 刘晓晴[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院老年病科,武汉430030

出　　处：《中华物理医学与康复杂志》2004年第5期291-293,共3页Chinese Journal of Physical Medicine and Rehabilitation

基　　金：湖北省科技攻关资助项目 (No .2 0 0 2AA30 1C0 3)

摘　　要：目的　探讨运动与活性维生素D联合作用对老年骨质疏松症患者骨量的影响。方法　将 89例确诊为老年骨质疏松症患者随机分为 2组 :阿法骨化醇 (α D3 )治疗组 (A组 ,45例 )和运动联合阿法骨化醇治疗组 (B组 ,44例 )。 2组患者每人每天服用元素钙 60 0mg、α D3 0 .2 5 μg ,B组患者同时进行有规律的运动训练。结果　单纯α D3 治疗后腰椎BMD明显上升 ,骨形成指标BGP水平明显升高 ,但骨吸收指标Pyd/Cr变化不明显 ;而联合治疗使腰椎和髋部的BMD均明显增加 ,并且骨形成指标BGP水平明显升高 ,骨吸收指标Pyd/Cr明显下降。结论　α D3 在促进老年骨质疏松症患者骨形成方面优于抑制骨吸收 ,对提高腰椎骨量具有优势。有氧运动联合α D3 不仅能增加老年骨质疏松症患者腰椎和股骨近端的骨量 ,同时能促进骨形成和抑制骨吸收 ,有效治疗老年人骨质疏松症 。Objective To study the effect of exercises plus active vitamin D on the bone mass of the elderly osteoporosis patients. Methods Eighty nine cases of elderly osteoporosis were divided into 2 groups at random, with 45 cases in Group A (control group) and 44 in Group B (treatment group). Every patients in these two groups takes 600mg calcium and 0.25μg α D 3 daily. At the same time, Group B conducts regular exercises. Results After the simple α D 3 treatment, the lumbar BMD increased significantly and the level of osseous formation index BGP increased, but the osseous absorption index PYD/Cr did not change significantly. However, after the combined treatment with α D 3 and exercise, the BMD at both the lumbar vertebra and the hip increased significantly, the level of osseous formation index BGP increased greatly and the osseous absorption index PYD/Cr decreased. Conclusion α D 3 treatment is more favorable for aged osteoporosis patients in stimulating osseous formation than in inhibiting osseous absorption, and it is advantageous in increasing the bone mass of the lumbar vertebra. The α D 3 treatment combined with aerobic exercise is helpful not only in increasing the bone mass of the lumbar vertebra and the hip in the elderly patients with osteoporosis, but also in stimulating osseous formation and inhibiting the osseous absorption.

关 键 词：运动 活性维生素D 老年骨质疏松症 骨量 代谢性骨病 

分 类 号：R58[医药卫生—内分泌]