血清可溶性转铁蛋白受体在儿童铁缺乏中的应用  

The value of determination of serum transferrin receptor in children with iron deficiency

作　　者：葛青玮[1] 刘家应[1] 高原[1] 蒋巍[1] 董小燕[2] 

机构地区：[1]上海交通大学附属儿童医院检验科,上海200040 [2]上海交通大学附属儿童医院营养研究室,上海200040

出　　处：《检验医学》2004年第3期197-199,共3页Laboratory Medicine

摘　　要：目的　探讨血清可溶性转铁蛋白受体 (sTfR)的检测在儿童铁缺乏诊断中的应用价值。方法　测定正常对照组 (5 0名 )和患儿组 (10 8例 )血红蛋白、sTfR以及有关铁参数。结果　sTfR静脉血、手指血检测结果经统计呈高度相关 (P <0 .0 0 1)。正常对照组、缺铁性贫血组和非缺铁性贫血组的sTfR测定结果分别为 (1.31± 0 .33)mg/L、(9.6 7± 6 .97)mg/L和 (1.79± 1.14 )mg/L ;缺铁性贫血组的sTfR与其他各组比较差异有显著性 (P <0 .0 1)。以 3.2mg/L为临界值 ,sTfR在未确定病因的贫血组和非贫血组中的阳性率分别为 34.6 %和15 .9%。随访的 5例缺铁性贫血患儿治疗前后sTfR检测结果差异有显著性 (P <0 .0 5 )。结论　血清sTfR检测可用于诊断和鉴别诊断缺铁性贫血与非缺铁性贫血 ,反映儿童铁缺乏的状况 ,作为疗效监测的指标。sTfR可用手指血检测 。Objective To study the value of determination of serum transferrin receptor (sTfR) in children with iron deficiency. Methods We measured hemoglobin, sTfR and several iron related parameters in 50 normal children and 108 patients. Results It was highly co relative between the concentration of sTfR in venous and capillary blood ( P <0.001 ). The mean levels of sTfR in 50 normal children, children with iron deficient anemia and children with non iron deficient anemia were ( 1.31 ±0.33 ) mg/L, ( 9.67 ±6.97 ) mg/L and ( 1.79 ±1.14 ) mg/L respectively. There were significant differences in sTfR mean concentrations between iron deficient anemia group and other two groups ( P <0.01 ). The positive rates of sTfR in uncertain cause anemia and nonanemia groups were 34.6% and 15.9% . There were significant differences in sTfR mean concentrations in 5 patients before and after treatment ( P <0.01 ). Conclusions The determination of sTfR can be used to diagnose and distinguish the iron deficient anemia, reflect the state of iron deficiency. It also can be an index of curative effect. sTfR can be measured with capillary blood, especially suitable for children.

关 键 词：血清可溶性转铁蛋白受体 sTfR 儿童 铁缺乏 生理性贫血 

分 类 号：R591.1[医药卫生—内科学]