血清尿酸与冠心病的关系  

Relationship between Serum Uric Acid and Coronary Heart Disease

作　　者：夏大胜[1] 蔡林[1] 李超[1] 张菁[1] 党群[1] 刘书坤[1] 

机构地区：[1]天津市第一中心医院心内科,300192

出　　处：《天津医药》2004年第6期330-332,共3页Tianjin Medical Journal

摘　　要：目的 :探讨血清尿酸水平是否与冠心病相关。方法 :经冠状动脉造影确诊的冠心病患者98例和非冠心病患者72例。分别测定血清尿酸及血脂水平。结果 :冠心病患者血清尿酸水平显著高于对照组 (P<0.01) ,相关分析显示血清尿酸水平与冠脉狭窄指数、年龄、甘油三酯、低密度脂蛋白胆固醇、体质量指数呈正相关 (P<0.05或P<0.01)。多因素回归分析显示 ,血清尿酸与冠心病的发生和冠脉狭窄指数无明显相关。结论 :高尿酸血症不是冠心病的独立危险因素。Objective:To explore the association of serum uric acid with coronary heart disease(CHD).Methods:Ninety-eight patients with CHD proved by angiography and72control subjects without CHD were included in this study,and serum uric acid and blood lipid were determined.Results:Serum uric acid level in CHD patients was markedly higher compared with that in control subjects(P<0.01).Correlation analysis reˉsults showed that serum uric acid level was positively and significantly related to coronary stenosis index,age,lnTG,LDL-C,and body mass index(P<0.05or P<0.01,respectively).Analyzed with multivariate Logistic and stepwise regression analysis,serum uric acid did not have obvious relation with the occurrence of CHD and coronary stenosis index.Conclusion:Elevated serum uric acid is not an independent risk factor for CHD.

关 键 词：血清 尿酸 冠心病 危险因素 

分 类 号：R541.4[医药卫生—心血管疾病]