血管紧张素转化酶基因多态性与妊娠高血压综合征的关系  

Relationship between Insertion/deletion Polymorphism of Angiotensin Converting Enzyme Gene and Pregnancy-induced Hypertension Syndrome

作　　者：王金和[1] 步天栩[1] 王艳娟[1] 程佩兰[1] 

机构地区：[1]天津医科大学总医院生化科,300052

出　　处：《天津医药》2004年第6期339-341,F003,共4页Tianjin Medical Journal

摘　　要：目的 :探讨血管紧张素转化酶 (ACE)基因插入(I)/缺失 (D)多态性与妊娠高血压综合征 (妊高征 )的关系。方法 :应用聚合酶链反应 (PCR)方法检测41例妊高征患者和50例正常妊娠者的ACE基因型 ,同时检测血浆ACE水平。结果 :妊高征组的DD基因型频率及D等位基因频率分别为39 %和61 % ,均高于对照组的相应频率18 %和38 % ,差别有统计学意义 (P<0.05)。DD基因型的ACE活性显著高于其他2种基因型。结论 :ACE基因缺失多态性可能为妊高征发病的重要遗传因素 ,ACE活性受到基因的调控。Objective:To identify the relationship between the insertion/deletion(I/D)polymorphism of anˉgiotensin converting enzyme(ACE)gene and pregnancy-induced hypertension syndrome(PIH).Methods:ACE genotype was examined by polymerase chain reaction(PCR)in41patients with PIH and50normal conˉtrols.The activity of plasma ACE was measured simultaneously.Results:The frequency of DD genotype and the frequency of deletion allele in PIH were39%and61%respectively.They were higher than those in the normal controls(P<0.05).The activity of ACE in the population with DD genotype was higher than the others.Conclusion:The DD genotype of ACE gene is probably an important hereditary factor of PIH.ACE activity can be controlled by the gene for the cause of higher activity of DD genotype.

关 键 词：血管紧张素转化酶 基因多态性 妊娠高血压综合征 聚合酶链反应 基因缺失 

分 类 号：R714.246[医药卫生—妇产科学]