蛋白聚糖在发育期大鼠大脑皮质的表达  

THE EXPRESSION OF AGRIN IN RAT CORTEX DURING THE POSTNATAL TIME

作　　者：王唯析[1] 刘丙方[2] 高尔静[2] 徐群渊[2] 

机构地区：[1]西安交通大学医学院人体解剖学与组织胚胎学教研室,西安710061 [2]首都医科大学北京神经科学研究所,北京100054

出　　处：《解剖学报》2004年第3期253-256,共4页Acta Anatomica Sinica

摘　　要：目的　观察蛋白聚糖 (agrin)在生后大脑皮质不同发育阶段的表达 ,探讨其与大脑皮质发育的关系。方法　免疫组织化学方法。　结果　Agrin在生后不同发育阶段的表达变化明显。生后第 1d ,agrin的表达很低 ,第2d开始迅速上升 ,6d时达到高峰 ,以后逐渐下降 ,第 4周时降至成年鼠水平。并且 ,agrin的表达与大脑皮质各层神经元发育顺序不尽一致。　结论　Agrin是一种与大脑皮质发育有关的蛋白聚糖 ,它对神经元的发育成熟可能有重要作用。Objective To observe the expression of heparan sulfate proteoglycan(HSPG)-Agrin in rat cortex of postnatal time in order to understand the relation between the development of cortex and agrin. Methods We performed immunohistochemical analysis of agrin expression in the postnatal rat cortex with agrin-specific polyclonal antibody. Results Agrin expression was shown to have significant differences in the different periods of postnatal time.It increased from postnatal 2 day(p2) to postnatal day 6(p6),then declined steadily after p6 and reached adult levels by 4w.In this periold of time,agrin has different expression peak following to the cortex layer development.Conclusion:Agrin is related to the development of cortex and may play an important role in the developing of central nervous system.;

关 键 词：蛋白聚糖 脑发育 免疫组织化学 大鼠 

分 类 号：Q593.4[生物学—生物化学]