儿童支原体肺炎的免疫功能测定  

Immune Function Test in Children with Mycoplasma Pneumonia

作　　者：钟小兰[1] 亢安娜[1] 杨丽君[1] 刘波[1] 张宁 

机构地区：[1]中国人民解放军第458医院儿科,广东广州510602 [2]广州市第六人民医院儿科,广东广州510632

出　　处：《广州医学院学报》2004年第1期34-36,共3页Academic Journal of Guangzhou Medical College

摘　　要：目的 :了解肺炎支原体肺炎 (MPP)不同年龄患儿体液免疫及细胞免疫功能的变化及其在MPP发病机制中的作用。方法 :收集 1～ 5岁MPP病例 2 8例分为急性期组和恢复期组 2组 :另设 1～ 5岁健康儿童 2 0例为对照组 ;收集 5～ 12岁MPP病例 5 0例 ,分为急性期组和恢复期组 2组 ,另设 5～ 12岁健康儿童 5 0例为对照组。测定外周血IgG、IgM、IgA和T淋巴细胞亚群CD4 + 、CD8+ 。结果 :IgG、IgA、IgM、CD8+ 在 1～ 5岁年龄急性期组、恢复期组、对照组 3组之间检测差异有统计学意义 (0 .0 1<P <0 .0 5 ) ,恢复期高于急性期组及对照组 (P <0 .0 5 ) ,急性期组与对照组之间无明显差别 (P >0 .0 5 )。CD4 + 及CD4+ /CD8+ 比值 3组之间检测差异有统计学意义 (0 .0 1<P <0 .0 5 ) ,恢复期组低于急性期组及对照组 (P <0 .0 5 ) ,急性期组与对照组之间无明显差异 (P >0 .0 5 )。IgG、IgA、IgM、CD8+ 在 5～ 12岁年龄恢复期组高于急性期组 ,急性期组高于对照组 ,3组之间差异有显著统计学意义 (P <0 .0 1)。CD4 + 、CD4 + /CD8+ 恢复期组低于急性期组 ,急性期组低于对照组 ,3组之间差异有显著统计学意义 (P <0 .0 1)。结论 :免疫损伤在小儿MPP的发病机制中起着重要作用 ,年龄越小 ,机体产生的免疫反应越轻微 ,恢复越快 ;Objective:To investigate the humoral and cellular immunity in children with mycoplasma pneumonia (MPP). Methods: 28 children with MPP aged 1～5 were divided into acute-stage and convalescence groups, and another 20 normal children of the same age range were recruited as controls. Similarly, 50 children with MPP aged 5～12 were divided into acute-stage and convalescence groups, and another 50 normal children of the same age range were recruited as controls. IgG, IgM, IgA and T-lym subgroups of these subjects were studied. Results: among subjects aged 1～5, levels of IgG, IgA, IgM and CD8 + of convalescence group were higher than those in acute-stage and control groups (P<0.05), but were not different between the latter two (P>05). CD4 + level and CD4 +/CD8 + of convalescence group were lower than those of acute-stage group and control group (P<0.05) but were not different between the latter two (P>05). Among subjects aged 5～12, levels of IgG, IgA, IgM and CD8+ of the groups in order was: convalescence group > acute-stage group > control group (P<0.01). CD4 + level and CD4 +/CD8 + of the groups in order was : convalescence group < acute-stage group < control group (P<0.01). Conclusion: Immune damage plays an important role in the pathogenesis of children MPP. The immune response is milder in younger children with rapid recovery and gets more severe in elder children.

关 键 词：小儿 肺炎支原体肺炎 免疫功能 

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