FGF/胶原蛋白复合海绵的皮内刺激试验和短期肌肉植入试验  

Intracutaneous stimulation test and shortterm muscle embedding test of FGF/Collagen compound sponge

作　　者：丁珊[1] 李校堃[1] 许华[1] 邓卓仪[1] 吴大明[1] 

机构地区：[1]暨南大学医药生物技术研究开发中心,广州市510630

出　　处：《医疗卫生装备》2004年第6期8-9,共2页Chinese Medical Equipment Journal

基　　金：国家"十五"科技攻关项目:生物医用材料一促神经损伤修复生物海绵材料(2001BA706B17-A)资助。

摘　　要：目的:评估FGF/胶原蛋白复合海绵在动物体内的生物相容性。方法:由不同原料制备的FGF/胶原蛋白复合海绵,分别进行以下生物学测试;(1)皮内刺激试验;(2)短期肌肉植入试验,实验数据根据标准进行分析和评估。结果:在急性眼刺激试验和皮内刺激试验中,2种供试品评分均为0分,表明它们对组织均无刺激性;在短期肌肉植入试验中,2种供试品在组织内无明显的炎症排斥反应,能够在短期内被降解吸收。结论:供试品的生物学测试结果显示了FGF/胶原蛋白复合海绵具有较好的生物相容性,在临床植入医用等领域有应用潜力。In this paper, the biological compatibilities of FGF/Collagen compound sponges are evaluated. Intracutaneous stimulation test and shortterm muscle embedding test of FGF/Collagen compound sponges made of different materials are performed. Experimental data are analyzed and evaluated according to the standard. The two sponges get marks of 0 in acute eye stimulation test and intracutaneous stimulation test, thus they are not stimulating to tissues. In shortterm muscle embedding test, they don't lead to inflammation reactions and can be degraded and absorbed in short term. FGF/Collagen compound sponge proves good biological compatibility and has a cheerful prospect in medicine.

关 键 词：FGF 胶原蛋白复合海绵 皮内刺激试验 肌肉植入试验 生物学测试 

分 类 号：R318.08[医药卫生—生物医学工程]