拓扑替康对大鼠的胚胎毒性及致畸性研究  

Embryotoxicity and Teratogenicity Study of Topotecan in Rats

作　　者：金卫红[1] 汪岱迪[1] 陆益红[1] 

机构地区：[1]江苏省药品检验所,江苏南京210008

出　　处：《中国药业》2004年第6期27-28,共2页China Pharmaceuticals

摘　　要：目的观察拓扑替康对大鼠的致畸作用和胚胎毒性。方法在受孕大鼠致畸敏感期(受孕后第6～15d),拓扑替康静脉给药,剂量分别为0.200,0.067,0.022mg/kg。结果拓扑替康使受孕母鼠和胎鼠体重减轻,吸收胎数增多,胎鼠骨骼发育迟缓,高中剂量组中胎鼠骨骼及内脏均有畸形发生。结论拓扑替康有较强的致畸作用和胚胎毒性作用。Objective:To observe the embryotoxicity and teratogenicity of topotecan in rats,Methods:Rats were administered at 0.200,0.067,0.022 mg/kg of IV topotecan on day of the gestation(d6～d15),Results:As compared to the control(NS),topotecan was toxic to pregnant rats and induce embryotoxicity,It increased resorption of fetuses and dead fetuses,reduced the body weight of the fetuses and delayed skeletongency,Especially,skeletal malformation and visceral deformity of survival fetuses were observed at high dose of topotecan, Conclusion:The results indicated that topotecan had teratogenic and embryotoxic effects on rats in this experiment,

关 键 词：拓扑替康 致畸性 胚胎毒性 大鼠 

分 类 号：R965.3[医药卫生—药理学] R979.1[医药卫生—药学]