川蛭口服液对兔全脑缺血-再灌注模型脑保护作用的SPECT实验研究  

The Brain Protective Effect of Chuanzhi Oral Liquid on the Rabbit Model with Ischemic Reperfusion

作　　者：于东平[1] 杨爱英 李云峰[1] 战克勤[1] 杨秀英[1] 

机构地区：[1]山东省潍坊市人民医院,山东潍坊261041 [2]山东省潍坊市立医院,山东潍坊261041

出　　处：《中国药业》2004年第6期28-29,共2页China Pharmaceuticals

摘　　要：目的观察川蛭口服液对兔全脑缺血-再灌注模型的脑保护作用。方法应用SPECT脑显像技术,分析兔脑结构的受损情况。结果药物组兔在再灌注10min和30min时,稀疏区和缺损区的病灶容积指数(DV)均低于对照组兔;除缺损区rCBF外,药物组兔在两个时刻稀疏区的rCBF均高于对照组兔;两组兔的立体图像分析结果显示,对照组兔大部分脑结构受损,药物组兔脑结构受损明显要轻。结论川蛭口服液具有明显减轻模型兔缺血-再灌注损伤和保护脑功能的作用。Objective:To observe the brain protective effect of chuanzhi oral liquid on the model rabbit with ischemic reperfusion,Methods:To analyze the injury area of rabbit brain by using SPECT technology,Results:When reperfusion occured at 10 min and 30 min,DV of sparse area and deficient area in treatment group were lower than that in control group,but rCBF was higher,Conclusion:Chuanzhi oral liquid could relieve the ischemic reperfusion injury and protect brain tissure,

关 键 词：川蛭口服液 兔全脑缺血-再灌注模型 SPECT脑显像技术 

分 类 号：R965[医药卫生—药理学] R285.5[医药卫生—药学]