系数倍率法测定麻药膏中盐酸利多卡因含量  

Determination of Lidocaine Hydrochloride by K-ratio Spectrophotometry

作　　者：罗东[1] 冉光炳[1] 何蓉[1] 

机构地区：[1]第三军医大学西南医院药学部,重庆400038

出　　处：《中国药业》2004年第6期34-35,共2页China Pharmaceuticals

摘　　要：目的测定麻药膏中盐酸利多卡因的含量。方法采用系数倍率法,选择波长对为263nm,270nm,系数K=0.8467。结果盐酸利多卡因相关系数r=0.9998,其浓度在0.246～0.574mg/mL范围内与吸收度呈良好的线性关系,平均回收率为98.29%,RSD=1.86%(n=5)。结论系数倍率法简便、可靠,适用于麻药膏中盐酸利多卡因的质量控制。Objective:To determine the content of lidocaine hydrochloride in anesthetic cream,Methods:K-ratio spectrophotometry was used with the wavelenghs at 263 nm,278 nm respectively and K-ratio was 0.846 7,Results:The correlation coefficient was 0.999 8,and the linear relation of analysis was good in the range of 0.246～0.574 mg/mL,The average recovery was 98.29%,and RSD was 1.86%(n=5), Conclusion:K-ratio spectrophotometry is rapid,convenient and accurate for determining the content of lidocaine hydrochloride,and suitable for the quality control of lidocaine hydrochloride in anesthetic cream,

关 键 词：盐酸利多卡因 系数倍率法 麻药膏 含量测定 

分 类 号：R927.2[医药卫生—药学] R971.2