基于Au/BiOBr-ZnIn₂S₄的光电化学传感器对血清素超灵敏检测  

Au/BiOBr-ZnIn2S4 Based Photoelectrochemical Sensor for Ultrasensitive Detection of Serotonin

作　　者：郭旭 蔡燕[1] 姚勇 陈婷婷[1] 

机构地区：[1]南通大学化学化工学院,江苏 南通

出　　处：《分析化学进展》2023年第3期330-339,共10页Advances in Analytical Chemistry

摘　　要：目的:本研究通过溶剂热法制备溴氧化铋(BiOBr)纳米花,然后用原位生长法,在BiOBr表面生长一层ZnIn2S4,制备BiOBr-ZnIn2S4复合材料。此外,还通过热还原法制备了尺寸均一的金纳米粒子(Au NPs),将二者复合后(Au/BiOBr-ZnIn2S4)用于血清素(5-hydroxytryptamine, 5-HT)的光电化学检测。Au/BiOBr-ZnIn2S4复合物,在检测血清素时有显著的光电流响应,这主要原因是:首先,在可见光照下,BiOBr能持续的产生光生电子(e−)和空穴(h+),电子流动产生光电流,并且h+可以加速待测物溶液中的血清素的氧化,有效增强光电流强度;其次,通过原位生长法合成BiOBr-ZnIn2S4复合材料可以提高载流子的分离和转移效率,从而抑制电子–空穴对的重组,提高光电流;接着,Au NPs的局域表面等离子共振效应(LSPR)以及较高的电导率,可以增加电化学反应速率以及电荷传递速率,进一步增加光电流响应;最后,通过三种材料的协调作用,实现对血清素的超灵敏检测。该光电传感器检测血清素时的浓度范围在0.1~100 μM之间,检出限为0.04 μM,表明基于Au/BiOBr-ZnIn2S4复合物的光电化学传感器对血清素具有较好的检测效果。该光电化学传感器还拥有制作简单、稳定性好和灵敏度高等优点,为今后这类生物小分子检测传感器的构建提供了思路。Purpose: In this study, bismuth bromide oxide (BiOBr) nanoflowers were prepared by solvothermal method, and then a layer of ZnIn2S4 was grown on the surface of BiOBr by in situ growth method to prepare BiOBr-ZnIn2S4 composites. In addition, uniformly sized gold nanoparticles (Au NPs) were prepared by thermal reduction, and the two were compounded (Au/BiOBr-ZnIn2S4) for the photoelectrochemical detection of serotonin (5-hydroxytryptamine, 5-HT). Au/BiOBr-ZnIn2S4 complex has a significant photocurrent response when detecting serotonin, which is mainly because: first, under visible light, BiOBr can continue to produce photogenerated electrons (e−) and holes (h+), electron flow generates photocurrent, and h+ can accelerate the oxidation of serotonin in the solution to be analyte, effectively enhancing the photocurrent intensity;Secondly, the BiOBr-ZnIn2S4 composite synthesized by in situ growth can improve the separation and transfer efficiency of carriers, thereby inhibiting the recombination of electron-hole pairs and increasing the photocurrent. Then, the local surface plasmon resonance effect (LSPR) and high conductivity of Au NPs can increase the electrochemical reaction rate and charge transfer rate, and further increase the photocurrent response. Finally, the ultrasensitive detection of serotonin is achieved through the coordinated action of the three materials. The concentration range of serotonin detected by the photoelectric sensor was between 0.1~100 μM, and the detection limit was 0.04 μM, indicating that the photoelectrochemical sensor based on Au/BiOBr-ZnIn2S4 complex had a good detection effect on serotonin. The photoelectrochemical sensor also has the advantages of simple production, good stability and high sensitivity, which provides ideas for the construction of such biological small molecule detection sensors in the future.

关 键 词：金纳米粒子 溴氧化铋 硫化铟锌 生物小分子 光电化学传感器 

分 类 号：O64[理学—物理化学]