胎盘生长因子在下肢动脉斑块中表达的相关性研究  

Correlation of Placental Growth Factor Expression in Arterial Plaque of Lower Extremity

作　　者：魏凯凯 万圣云[1] 孔令尚[1] 丁洋[1] 

机构地区：[1]安徽医科大学第二附属医院,安徽 合肥

出　　处：《临床医学进展》2019年第11期1276-1281,共6页Advances in Clinical Medicine

摘　　要：目的:探讨人股动脉粥样硬化斑块中胎盘生长因子表达水平及临床意义。希望进一步探讨下肢动脉疾病的发病机制。方法:研究共纳入下肢动脉斑块标本30例(其中男性15例,女性15例,平均年龄:66岁),所有病例术前均有间歇性跛行病史,术前均经下肢动脉CTA或血管造影等检查,证实为下肢动脉硬化闭塞症。同时选取因外伤损伤股动脉后,行股动脉搭桥术中切除的股动脉标本10例(男性7例,女性3例,平均年龄:61岁)作为对照组。采用免疫组化方法检测PLGF蛋白表达含量水平。结果“各组PLGF水平比较((正常对照组(0.0005 ±1.52 ×10?7) vs.动脉斑块组(0.0388 ±1.1 ×10?3),P 【0. 05),差异有统计学意义。结论:我们的研究发现,下肢动脉疾病患者动脉斑块PLGF水平明显高于正常对照者,这可能与PLGF可以促进动脉粥样硬化斑块的增长和导致斑块不稳定有关。Objective: To investigate the expression of placental growth factor in human femoral atherosclerotic plaque and its clinical significance. We hope to further explore the pathogenesis of ASO. Methods: A total of 30 lower extremity arterial plaque specimens (15 males and 15 females, mean age: 66 years) were included in the study. All patients had a history of intermittent claudication before operation. All patients were confirmed as arteriosclerosis obliterans by lower extremity CTA or angiography before operation. Meanwhile, 10 cases (7 males and 3 females, mean age: 61) of femoral artery specimens removed during femoral artery bypass grafting after femoral artery injury were selected as the control group. The expression of PLGF protein was detected by immunohistochemistry. Result: The PLGF levels of each group were significantly different from those of the normal control group ((0.0005 ±1.52 ×10?7) vs. the arterial plaque group (0.0388 ±1.1 ×10?3), P

关 键 词：外周动脉疾病 动脉斑块 人胎盘生长因子 

分 类 号：R71[医药卫生—妇产科学]