脊柱关节炎肌腱端炎病理生理机制的研究进展  

Research Progress in Pathophysiological Mechanism of Enthesitis in Spondyloarthritis

作　　者：丁泓百 朱琦 

机构地区：[1]上海中医药大学,上海 [2]上海中医药大学附属光华医院,关节内科,上海

出　　处：《临床医学进展》2019年第11期1306-1314,共9页Advances in Clinical Medicine

基　　金：上海市科委课题(16401930500)、上海市卫健委课题(2016LP050)、2017年度“浦江风湿青年医师培育计划”(SPROG201709).

摘　　要：目的:肌腱端是脊柱关节炎(SpA)这类疾病中骨骼炎症的主要靶点之一。过去的研究低估了SpA中肌腱端炎的发病率,近些年随着影像仪器的发展,无临床症状的肌腱端炎能够被诊断出。对肌腱端炎发病机制的研究有利于制定SpA疾病的早期诊断和治疗策略。方法:检索近几年国内外关于肌腱端炎的文献,进行总结分析。结果:发现SpA肌腱端炎的病理生理机制包括:机械应激与免疫激活、间充质干细胞增殖以及新骨形成。结论:若能说明肌腱端炎与新骨形成的具体联系,将会对脊柱关节炎的治疗有很大启发。Objective: The entheses is one of the main targets of the bone inflammation in the disease such as Spondyloarthritis (SpA). In the past, the incidence of enthesitis in SpA has been underestimated. In recent years, with the development of the image instrument, enthesitis without clinical symptoms can be diagnosed. The study of the pathogenesis of the enthesitis is beneficial to the development of early diagnosis and treatment strategies of SpA disease. Methods: The literature on the enthesitis at home and abroad in recent years was searched, and the summary and analysis were carried out. Results: The pathological and physiological mechanism of the enthesitis of SpA was found to include the mechanical stress and the immune activation, the proliferation of the mesenchymal stem cells and the formation of new bone. Conclusion: It is a great inspiration for the treatment of SpA if the specific relationship between the enthesitis and the formation of the new bone is indicated.

关 键 词：脊柱关节炎 肌腱端炎 机制 

分 类 号：R68[医药卫生—骨科学]