甲硫氨酸腺苷转移酶基因与临床研究进展  

Advances in the Study of Adenosyltransferase Gene of Methionine

作　　者：蓝家富[1] 李近都 李天资[1] 

机构地区：[1]右江民族医学院附属医院,广西 百色 [2]广西医科大学附属肿瘤医院,广西 南宁

出　　处：《临床医学进展》2020年第3期165-171,共7页Advances in Clinical Medicine

基　　金：国家自然科学基金(81060028,81560460),广西重大专项基金(桂科重1598005-9),广西中青年教师基础能力提升基金(2018KY0450),百色市科技局资助项目(百科20193109)。

摘　　要：研究表明甲硫氨酸腺苷基转移酶是参与甲基、巯基和丙基等三种代谢途径的催化酶,参与生物体内的转甲基、转硫和转氨丙基等多种重要的细胞代谢过程,因基因突变造成甲硫氨酸腺苷基转移酶功能缺乏,而导致血液中甲硫氨酸的浓度因甲硫氨酸的堆积而升高。目前认为甲硫氨酸腺苷基转移酶基因位点的变异,参与基因转录,细胞增殖等导致一些中间代谢物质水平发生异常变化,成为动脉硬化,肝病,癌症,抑郁症,老年痴呆症,空泡性脊髓病和骨关节炎的发病因素,是临床诊断标识,疗效观察和药物靶标研究的热点。The results show that methionine Adenylyl transferase is a catalytic enzyme of methyl group, mercapto group and propyl group, which is involved in many important cell metabolic processes, such as methyl group, Sulfur Group and aminopropyl group, a genetic mutation that causes a lack of function for the enzyme, Methionine, causes blood concentrations to rise with the build-up of methionine. It is now thought that mutations in the MTCT gene, which is involved in gene tran-scription, cell proliferation, and so on, lead to abnormal levels of some of these metabolites, which can lead to arteriosclerosis, liver disease, cancer, depression, and Alzheimer’s disease, the etio-logical factors of Alveolar Ridge disease and osteoarthritis are the hot spots of Clinical Diagnosis, curative effect and Drug Target Research.

关 键 词：高甲硫氨酸血症 甲硫氨酸腺苷转移酶基因 甲基循环 

分 类 号：R28[医药卫生—中药学]