川崎病冠脉损害的干细胞治疗研究进展  

Research Progress of Stem Cell Therapy for Coronary Artery Damage in Kawasaki Disease

作　　者：万萱 冯建英 严晓华[1] 张西嫔[1] 王菊艳[1] 李晓红[1] 李思琼 成钧 肖成 焦富勇[1] 

机构地区：[1]陕西省人民医院儿童病院,陕西 西安 [2]西北妇女儿童医院儿科,陕西 西安 [3]西安北车医院儿科,陕西 西安

出　　处：《临床医学进展》2021年第2期826-830,共5页Advances in Clinical Medicine

摘　　要：川崎病是一种具有明显季节性和区域流行性的疾病,好发于5岁以下儿童,表现为急性自限性的全身性血管炎,累及中小动脉,特别是冠状动脉病变。目前发病呈增高趋势,大约15%~25%未经系统治疗的儿童最终发展成冠状动脉损害,成为发达国家儿童获得性心脏病的最常见原因。目前干细胞治疗小鼠川崎病模型所致的冠脉损害取得重要进展,现就干细胞治疗川崎病冠脉损害的形成进行简要综述。Kawasaki Disease (KD) is an acute, self-limited systemic vasculitis that affects the middle and small arteries, especially the coronary arteries. The incidence is currently on the rise, with about 15 to 25 per cent of children without systemic disease eventually developed coronary artery damage, becoming the most common cause of child-acquired heart disease in the countries where it occurs. At present, stem cell therapy for Kawasaki Disease in mice has made important progress. This article reviews the formation of stem cell therapy for Kawasaki disease.

关 键 词：川崎病 冠脉损害 干细胞 

分 类 号：R54[医药卫生—心血管疾病]