静注大剂量丙种球蛋白与溶血病新生儿坏死性小肠结肠炎发生关系的研究  

Study on the Relationship between Intravenous Injection of Large Doses of Intravenous Immunoglobulin and Necrotizing Enterocolitis in Neonates with Hemolytic Disease

作　　者：王孟兰 姜红[2] 

机构地区：[1]青岛大学附属青岛市海慈医院,山东 青岛 [2]青岛大学附属医院,山东 青岛

出　　处：《临床医学进展》2021年第3期1095-1101,共7页Advances in Clinical Medicine

摘　　要：目的:通过对足月ABO溶血病新生儿静注大剂量丙种球蛋白后血清I-FABP、D-Lac水平的测定,探讨静注大剂量丙种球蛋白与溶血病新生儿坏死性小肠结肠炎发生的关系。方法:选择2018年12月至2019年12月我院新生儿科收治的足月ABO溶血病患儿60例,分为实验组及对照组。采用酶联免疫吸附法(ELISA)检测不同时间点血清中I-FABP、D-Lac水平,比较不同组内、组间血清I-FABP、D-Lac水平变化。结果:实验组血清I-FABP水平分别为:(1.45 ±0.26) ng/ml、(3.78 ±0.38) ng/ml和(3.39 ±0.44) ng/ml,组内比较差异有统计学意义(P 0.05);两组组间比较:F = 530.188, P 0.05);两组组间比较差异有统计学意义(F = 300.0, P 【0.05)。实验分析中检测时间与分组因素存在交互作用,通过简单效应的程序分析,提示差异主要与分组因素相关。结论:静注大剂量丙种球蛋白可引起肠道粘膜损伤,是溶血病新生儿NEC发生的一个高危因素。Objective: To investigate the relationship between high dose of Intravenous immunoglobulin and necrotizing enterocolitis in neonates with full-term hemolytic disease (ABO) by measuring the serum I-FABP and D-LAC levels after intravenous injection of high dose intravenous immunoglobulin. Methods: A total of 60 children with full-term ABO hemolytic disease admitted to the neonatal department of our hospital from December 2018 to December 2019 were selected and divided into the experimental group and the control group. Serum I-FABP and D-LAC levels were detected by enzyme-linked immunosorbent assay (ELISA) at different time points, and the changes of serum I-FABP and D-LAC levels in different groups and between groups were compared. Results: The levels of serum I-FABP in the experimental group were (1.45 ±0.26) ng/ml, (3.78 ±0.38) ng/ml and (3.39 ±0.44) ng/ml, respectively, with statistical significance within the groups (P 0.05). Comparison between the two groups: F = 530.188, P 0.05). The difference between the two groups was statistically significant (F = 300.0, P

关 键 词：新生儿溶血病 静注丙种球蛋白 肠脂肪酸结合蛋白 D-乳酸 坏死性小肠结肠炎 

分 类 号：R72[医药卫生—儿科]